Effects of protein malnutrition on IL-6-mediated signaling in the liver and the systemic acute-phase response in rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Pei-Ra LingBruce R Bistrian

Abstract

This study examines the effects of malnutrition on IL-6 signaling pathways of rats fed 2% vs. 20% casein diets for 14 days. Effects of malnutrition on the abundance and IL-6-stimulated phosphorylation of signaling proteins in the JAK-STAT and MAP kinase pathways were examined in the liver. Changes of the acute-phase response as reflected by serum alpha(1)-acid glycoprotein (AG), TNF-alpha (TNF), and IL-1beta (IL-1) were compared in the two dietary groups at 0, 4, 8, 16, and 24 h after IL-6 administration. Under basal conditions, the abundance of the IL-6 receptor, gp130, JAK1, STAT1, and STAT3 proteins and levels of phosphorylation of ERK1/2 and p38 were significantly increased in the liver in the 2% casein group compared with the 20% casein group. With IL-6 stimulation, the increased phosphorylation per unit of protein of these signaling proteins was not different in the liver between the two groups. Before IL-6 stimulation, serum levels of TNF, IL-1, IL-6, and AG were significantly higher in the 2% casein group than in the 20% casein group. After bolus injection of IL-6, changes in IL-1 and AG were similar in the two dietary groups, although a slight decline in AG level was noted after 8 h of IL-6 administration in the 2% pro...Continue Reading

References

Jan 1, 1977·JPEN. Journal of Parenteral and Enteral Nutrition·G L BlackburnM F Smith
Apr 12, 1976·JAMA : the Journal of the American Medical Association·B R BistrianJ Naylor
Mar 11, 1992·The Journal of Surgical Research·T NimmanwudipongH C Polk
Nov 11, 1974·JAMA : the Journal of the American Medical Association·B R BistrianR Heddle
Jan 1, 1983·The Journal of Nutrition·S MoriguchiY Kishino
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Feb 1, 1995·Journal of Nutritional Science and Vitaminology·S TeshimaK Kishi
Mar 20, 1998·International Reviews of Immunology·T Hirano
Aug 26, 1998·The Biochemical Journal·P C HeinrichL Graeve
Nov 27, 1998·British Medical Bulletin·M H Golden
Dec 9, 1998·The American Journal of Physiology·K M AndrejkoC S Deutschman
Nov 24, 1999·Free Radical Biology & Medicine·H Sies
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M K HansenL R Watkins
Apr 27, 2000·The Journal of Surgical Research·R D KimR S Chari
Nov 4, 2000·Biochimica Et Biophysica Acta·T FournierD Porquet
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A A JacksonF Jahoor
Apr 12, 2002·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Semra Doğru-AbbasoğluMüjdat Uysal
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hajime NishioKoichi Suzuki
Nov 27, 2002·The American Journal of Clinical Nutrition·Marvin ReidFarook Jahoor
Jul 23, 2003·Current Pharmaceutical Design·L AmatiE Jirillo
Jan 9, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bruce A CooperCarol A Pollock

❮ Previous
Next ❯

Citations

Jul 17, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Shari E SmithPhyllis G Paterson
Aug 20, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Ilia BeberashviliJoshua Weissgarten
Apr 13, 2007·Expert Opinion on Drug Metabolism & Toxicology·Michael Murray
Sep 1, 2012·Drug and Chemical Toxicology·Jun XieLi Zhang
Jan 21, 2014·Progress in Cardiovascular Diseases·Jongha ParkKamyar Kalantar-Zadeh
Apr 21, 2009·Metabolism: Clinical and Experimental·Pei-Ra Ling, Bruce R Bistrian
Jan 6, 2009·Seminars in Nephrology·Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Jan 11, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Emilio González-ReimersMelchor Rodríguez-Gaspar
Jun 27, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christian S ShinabergerKamyar Kalantar-Zadeh
Aug 23, 2012·Periodontology 2000·Cyril O Enwonwu, Nathanael Salako
Feb 4, 2011·Journal of Renal Care·Lynn M TaylorCsaba P Kovesdy
Nov 8, 2005·Biochemical and Biophysical Research Communications·Barbara KroczynskaSylvie Y Blond
Nov 21, 2007·Brain Research·Ana Maria FeoliCarlos-Alberto Gonçalves
Mar 15, 2006·Seminars in Nephrology·Kamyar Kalantar-ZadehGregg C Fonarow
Aug 9, 2012·Toxicology Mechanisms and Methods·Hongxu LuLi Zhang
Dec 20, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fernanda C AmparoAntonio C Cordeiro
Oct 5, 2013·Best Practice & Research. Clinical Gastroenterology·Tugrul Purnak, Yusuf Yilmaz
Nov 1, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Connie M RheeKamyar Kalantar-Zadeh
Apr 26, 2017·KI Reports·Kamyar Kalantar-ZadehAlpesh N Amin
Aug 18, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nikki L JerniganThomas C Resta
Oct 4, 2006·Hemodialysis International·Kamyar Kalantar-Zadeh, Vaidyanathapuram S Balakrishnan
Apr 22, 2005·American Journal of Physiology. Cell Physiology·Rachel J WebbGeraint M H Thomas
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Kamyar Kalantar-ZadehDebbie Benner
Oct 8, 2005·Journal of Applied Physiology·Joanne L WrightAndrew Churg
Jun 27, 2006·American Journal of Physiology. Heart and Circulatory Physiology·James E FaberHua Zhang
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Kamyar Kalantar-Zadeh
Nov 7, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yuansheng GaoJ Usha Raj
Jan 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·James E FaberHua Zhang
Feb 12, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brad R S BroughtonThomas C Resta
Jul 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nikki L JerniganThomas C Resta

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