Effects of proton pump inhibitors on thyroid hormone metabolism in rats: a comparison of UDP-glucuronyltransferase induction

Biochemical Pharmacology
N MasubuchiO Okazaki

Abstract

The effects of proton pump inhibitors on thyroid hormone metabolism in rats were examined. Pantoprazole, omeprazole, and lansoprazole were administered repeatedly to female SD rats at doses of 5, 50, and 300 mg/kg/day for 1 week, and changes in UDP-glucuronyltransferase activities were examined. Increases in o-aminophenol UDP-glucuronyltransferase activity, which was measured as that responsible for the glucuronidation of thyroxine, were evident following 7-day high-dose administration of all the proton pump inhibitors tested. Of the three proton pump inhibitors investigated, o-aminophenol UDP-glucuronyltransferase activity was greatest following the high-dose administration of omeprazole. Androsterone UDP-glucuronyltransferase activity in rats treated with the proton pump inhibitors increased significantly, but these increases were smaller than those of o-aminophenol UDP-glucuronyltransferase. Pantoprazole and omeprazole treatment did not affect plasma T4 or T3 significantly, whereas lansoprazole treatment produced marked reductions in plasma T4 but did not affect plasma T3 significantly. After administration of 125I-labeled thyroid hormone to rats treated with the proton pump inhibitors, biliary excretion of radioactivity inc...Continue Reading

References

Mar 1, 1992·Toxicology and Applied Pharmacology·R A Barter, C D Klaassen
Jun 15, 1989·Toxicology and Applied Pharmacology·R M McClainJ C Downing
Jan 1, 1987·Hormone Research·J KöhrleR D Hesch
Jun 30, 1988·Toxicology and Applied Pharmacology·R M McClainJ M Armstrong
Jan 1, 1987·European Journal of Clinical Pharmacology·A J MacGilchristJ L Reid
Feb 1, 1973·The Journal of Endocrinology·C H Bastomsky, P D Papapetrou
Jun 1, 1968·Biochemical Pharmacology·J A Goldstein, A Taurog
Feb 1, 1995·Scandinavian Journal of Gastroenterology·J HotzK Rose
Feb 1, 1995·Alimentary Pharmacology & Therapeutics·K U Petersen
Oct 1, 1994·Alimentary Pharmacology & Therapeutics·H G DammannR Luehmann
Mar 1, 1993·Human & Experimental Toxicology·S JohnsonI K Smith
Jan 1, 1994·Alimentary Pharmacology & Therapeutics·G T Tucker
Feb 9, 1993·Biochemical Pharmacology·J A van RaaijK J van den Berg
Oct 1, 1995·Therapeutic Drug Monitoring·G R GrannemanJ H Cavanaugh

❮ Previous
Next ❯

Citations

Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Sing-Yung WuInder J Chopra
Jan 20, 2004·Critical Reviews in Toxicology·M E Bette MeekDorothy E Patton
Oct 30, 2007·The Journal of Toxicological Sciences·Ko OmuraTetsuro Urushidani
Feb 13, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lloyd LecureuxLois D Lehman-McKeeman
Feb 10, 2019·Cell Stress & Chaperones·Konstantinos PapamichaelEkaterini Tiligada
Aug 3, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Issac SachmechiPaul J Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.