PMID: 2493575Mar 1, 1989Paper

Effects of prototypic PCBs on benzo[a]pyrene mutagenic activity related to vitamin A intake

Mutation Research
P GrolierF Oesch

Abstract

The effects of vitamin A dietary intake (2 and 20 IU */g of food) on the mutagenic activity of benzo[a]pyrene (B(a)P) toward Salmonella typhimurium (TA98) were studied either in control rats or in animals treated by the PCB congeners 2,4,5,2',4',5'-hexachlorobiphenyl [2,4,5)2Cl) and 3,4,3',4'-tetrachlorobiphenyl [3,4)2Cl). (3,4)2Cl (a planar compound) strongly increased B(a)P monooxygenase (B(a)PMO) activity and glutathione transferase, (2,4,5)2Cl (a non-planar PCB) was a strong inducer of epoxide hydrolase and a weak inducer of B(a)PMO. Enzyme induction was not modified by changes in vitamin A dietary intake. A higher mutagenic effect was observed in the (3,4)2Cl group than in the (2,4,5)2Cl one. This could be related to the specific form of cytochrome P-450 induced by (3,4)2Cl. In the untreated animals, the activation of B(a)P was higher in the 2-IU group than in the 20-IU one. Conversely, in PCB-treated rats the mutagenic activity of B(a)P was higher in the 20-IU group than in the 2-IU one. PCB induction increased the liver content of vitamin C in both the 2-IU and the 20-IU groups but only increased the glutathione levels in the 2-IU groups. This suggests that glutathione content in cellular fractions may be one of the dete...Continue Reading

References

May 31, 1979·Annals of the New York Academy of Sciences·H YoshimuraM Miki
Nov 21, 1977·Biochemical and Biophysical Research Communications·J Van CantfortJ E Gielen
Sep 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M A PélissierR Albrecht
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Mar 10, 1971·Biochimica Et Biophysica Acta·E OeschJ Daly
May 1, 1983·Mutation Research·D M Maron, B N Ames

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Citations

Oct 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K PolasaK Krishnaswamy
Aug 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M A PélissierL W Robertson
May 1, 1997·Journal of the American Dietetic Association·R M Russell
Jan 1, 1990·Food Additives and Contaminants·E AntignacJ F Narbonne
Mar 20, 1992·Journal of Chromatography·V Lang

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