PMID: 6104841Jan 1, 1980Paper

Effects of psychotropic drugs on delta 9-tetrahydrocannabinol-induced long-lasting muricide

Psychopharmacology
M FujiwaraS Ueki

Abstract

The effects of psychotropic drugs on THC-induced long-lasting muricide were investigated in rats. Changes in open field activity (ambulation and rearing) of the rat were concurrently assessed as an index of behavioral toxicity. Imipramine-like antidepressants, atropine, and antiparkinsonism drugs exhibited a selective inhibitory activity on muricide, whereas the effects of neuroleptics, pentobarbital, diazepam, and methamphetamine were nonspecific. It is also suggested that cholinergic, catecholaminergic, and serotonergic mechanisms are involved in THC-induced muricide. This type of induced muricide appears to be a useful experimental model particularly suitable for the evaluation of antidepressants in correlation with brain amine dynamics.

References

Jun 1, 1976·Behavioral Biology·G A BarrJ L Gibbons
Aug 1, 1977·Japanese Journal of Pharmacology·T SegawaM Hosokawa
Feb 1, 1978·Pharmacology, Biochemistry, and Behavior·R Oishi, S Ueki
Oct 1, 1978·Physiology & Behavior·M Fujiwara, S Ueki
Jul 1, 1976·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·S UekiK Inoue
Nov 1, 1975·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·S UekiN Ibii
Jan 1, 1974·Psychological Bulletin·H H Avis
Nov 1, 1966·International Journal of Neuropharmacology·Z P HorovitzR C Leaf
Nov 1, 1974·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·S WatanabeS Ueki
Apr 1, 1974·Japanese Journal of Pharmacology·S NurimotoS Ueki
Nov 1, 1972·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·S UekiY Araki
Jan 1, 1972·Folia Psychiatrica Et Neurologica Japonica·S UekiN Ogawa
Jan 1, 1972·Neuropharmacology·L Valzelli, S Garattini
Oct 1, 1965·Life Sciences·Z P HorovitzR C Leaf
Aug 1, 1964·Journal of Comparative and Physiological Psychology·J S MYER

❮ Previous
Next ❯

Citations

Mar 1, 1984·Pharmacology, Biochemistry, and Behavior·M FujiwaraS Ueki
Aug 1, 1981·Journal of Clinical Pharmacology·R G Browne, A Weissman
Feb 27, 1988·British Medical Journal·E K RodrigoP Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here