Effects of psyllium vs. placebo on constipation, weight, glycemia, and lipids: A randomized trial in patients with type 2 diabetes and chronic constipation

Complementary Therapies in Medicine
Soltanian NoureddinAdibi Payman

Abstract

To compare the effects of baked psyllium supplementation versus those who received a placebo on constipation symptoms, body weight, glycemic and lipids control in patients with type 2 diabetes (T2D) and chronic constipation. In a single-blinded, randomized controlled trial, 51 patients with T2D and chronic constipation with body mass index (BMI) 20-47 kg/m2 received either 10 g of psyllium pre-mixed in cookies twice per day or placebo cookies for 12 weeks. Constipation symptoms, body mass index (BMI), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and lipid profile were determined at the beginning and end of 4, 8, and 12-week period. Constipation was evaluated with a stool diary (ROME III). The psyllium group showed improvement in constipation symptoms, body weight, glucose and lipid values compared with the baseline and the placebo group. Body weight and FPG decreased from baseline in the psyllium group (P < 0.001 and P = 0.056, respectively). The differences (95% CI) of absolute change of body weight (-2.0 (-3.0, -1.0) kg; P < 0.001), FPG (-13.6 (-24.3, -2.9) mg/dl; P = .040), and HbA1c (-1.7 (-2.9, -0.5)); P = 0.002) between the groups were statistically significant. Cholesterol (-21.5 (-25.6, -14.4); P < 0.0...Continue Reading

Citations

Mar 12, 2020·International Journal of Molecular Sciences·Xiang GaoMeiyan Sun
Jun 28, 2019·Therapeutic Advances in Gastroenterology·Theresa MeldgaardAsbjørn Mohr Drewes
Dec 12, 2020·Journal of Diabetes and Its Complications·Rebecca B N ConwayM Kathleen Figaro
Nov 10, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yajuan XieLulu Chen
Mar 27, 2021·The American Journal of Gastroenterology·Satish S C Rao, Darren M Brenner
Jun 26, 2021·World Journal of Diabetes·Marcio José Concepción ZavaletaLuis Alberto Concepción Urteaga
Jun 15, 2021·Saudi Journal of Biological Sciences·Sharifa AlkandariJiwan S Sidhu
Feb 13, 2020·Current Clinical Pharmacology·Maliha NaseerVeysel Tahan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.