PMID: 2500373Apr 1, 1989Paper

Effects of puberty on seizure frequency

Developmental Medicine and Child Neurology
S Niijima, S J Wallace

Abstract

Seizure frequency was documented before, during and in some cases after puberty for 12 patients with continuing generalised tonic-clonic seizures (GTCS) and for 14 with complex partial seizures (CPS) who were receiving anti-epileptic drugs. For the patients with GTCS there was a significant increase in seizure frequency during the pubertal growth-spurt, with a subsequent decrease after growth ceased. There appeared to be no relationship between puberty and the frequency of CPS. Both groups were more likely to have suboptimal plasma drug-levels during puberty, suggesting that medication was not the cause of the increased GTCS frequency. Further examination of hormonal levels in relation to frequency of GTCS during puberty could provide a better understanding of the influence of hormones.

Citations

Jan 1, 1992·Epilepsia·M J Morrell
Mar 1, 1991·Journal of Autism and Developmental Disorders·C Gillberg
Sep 1, 1990·Developmental Medicine and Child Neurology·M CosgroveS J Wallace
Oct 1, 1990·Developmental Medicine and Child Neurology·M J Clement, S J Wallace
Sep 14, 2021·Autism : the International Journal of Research and Practice·Xian LiuWen-Xiong Chen

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