Effects of pulse methylprednisolone on cell adhesion molecules in the synovial membrane in rheumatoid arthritis. Reduced E-selectin and intercellular adhesion molecule 1 expression

Arthritis and Rheumatism
P P YoussefM D Smith

Abstract

To investigate the effects of a 1,000-mg intravenous pulse of methylprednisolone succinate (MP) on cell adhesion molecule expression on the synovial vascular endothelium in patients with rheumatoid arthritis (RA). Sequential arthroscopic biopsy samples were taken before and 24 hours after MP administration (10 patients) and at the time of RA flare (2 patients) and after retreatment with MP (1 patient). Immunoperoxidase staining for E-selectin (CD62E), P-selectin (CD62P), intercellular adhesion molecule 1 (ICAM-1; CD54) and platelet-endothelial cell adhesion molecule (PECAM; CD31) was performed, and the staining was quantified by color video image analysis. MP caused a rapid (within 24 hours) and substantial decrease in the expression of E-selectin on the synovial vascular endothelium, with a smaller reduction in ICAM-1 expression on synovial vascular endothelium and the synovial lining. There were no similar effects on synovial membrane P-selectin or PECAM expression. A potential mechanism by which MP impairs neutrophil trafficking into inflamed RA joints might be by reducing E-selectin, and possibly, ICAM-1, expression in the synovial membrane.

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Citations

Oct 18, 2002·Arthritis and Rheumatism·Larry W Moreland, James R O'Dell
Jun 25, 2005·Annals of the Rheumatic Diseases·M D SmithUNKNOWN OMERACT synovial special interests group
Jan 30, 1999·Annals of the Rheumatic Diseases·I Gotis-GrahamH P McNeil
Jan 12, 2012·International Journal of Inflammation·R GurionL N Moorthy
Mar 4, 2005·Arthritis Research & Therapy·Lois L CavanaghRanjeny Thomas
Jun 6, 2009·Arthritis Research & Therapy·Erik af KlintStaffan Lindblad
Jun 7, 2005·Expert Opinion on Emerging Drugs·Jasper J HaringmanPaul P Tak
Jan 31, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Victor FattoriWaldiceu A Verri
Apr 19, 2005·Expert Opinion on Biological Therapy·Patrick LavigneJulio C Fernandes
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May 12, 2004·Osteoarthritis and Cartilage·Stefanie S BrennerUwe Bierbach
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Oct 14, 2016·BMC Musculoskeletal Disorders·A Dell'IsolaM Steultjens

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