Effects of purified zearalenone on selected immunological measurements of blood in post-weaning gilts

Animal Nutrition
Lijie YangZaibin Yang

Abstract

Zearalenone (ZEA), an estrogenic mycotoxin, is produced mainly by Fusarium fungi. Previous studies have indicated that acute ZEA exposure induced various damages in different species; however, its transparent hematotoxicity in female piglets at dietary levels of 1.1 to 3.2 mg/kg has not been shown. The present study was conducted to investigate the effects of dietary ZEA (1.1-3.2 mg/kg) on hematology, T lymphocyte subset, immunoglobulin, antibody titer, lymphocyte proliferation rate (LPR), and interleukin-2 (IL-2) in peripheral blood of post-weaning gilts. A total of 20 female piglets (Landrace × Yorkshire × Duroc), weaned at 42 d with an average body weight of 10.36 ± 1.21 kg were used in the study. Female piglets were kept in a temperature controlled room, divided into four treatments, and fed a diet based on corn-soybean meal-fishmeal-whey, with an addition of 0, 1.1, 2.0, or 3.2 mg/kg purified ZEA for 18 d ad libitum. Feed intake and refusal were measured daily and individual pigs were weighed weekly. Blood and serum samples were collected for selected immunological measurements. Female piglets fed different levels of dietary ZEA grew similarly with no difference in feed intake. Hematological values including leukocytes, pl...Continue Reading

Citations

Aug 27, 2019·Critical Reviews in Food Science and Nutrition·Ankita RaiAnurag Tripathi
Nov 3, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Promy VirkMai Elobeid
Mar 2, 2021·Frontiers in Veterinary Science·Lan ZhengSung Woo Kim
Apr 4, 2021·Toxins·Cristina Valeria BulgaruIonelia Taranu
Nov 17, 2020·Toxicon : Official Journal of the International Society on Toxinology·Fengyang WuBaojiang Chen

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Methods Mentioned

BETA
Immunocytometry
ELISA
density gradient equilibrium centrifugation

Software Mentioned

Cell Quest
SAS

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