Effects of purine compounds on cholinergic nerves. Specificity of adenosine and related compounds on acetylcholine release in electircally stimulated guinea pig ileum

European Journal of Pharmacology
E HayashiM Kumitomo

Abstract

The action of 21 purine compounds on the twitch response of the electrically stimulated guinea pig isolated ileum has been investigated. Adenosine and related compounds produced a dose-dependent depression of the response. Adenosine was the most potent and 2'-deoxyadenosine had one hundredth the potency of adenosine. Adenine, hypoxanthine, inosine, IMP, ITP, xanthine, xanthosine, XMP, XTP, guanine, GMP and GTP were ineffective at concentrations less than 1 mM. Adenosine (30 microgram) reduced the electrically induced ACh output from the ileal strips. The dose--depression curve for adenosine (0.1--30 microgram) was shifted to the right in the presence of xanthine derivatives and of these, theophylline was the most potent inhibitor of adenosine. On the other hand, dipyridamole (0.1--1 microgram) and hexobendine (0.1--1 microgram) shifted the curve to the left. They markedly inhibited 3H-adenosine uptake into the ileum. Theophylline (0.1 mM), dipyridamole (0.3 microgram) and hexobendine (0.3 microgram) did not affect tetrodotoxin-, adrenaline-, strychnine- and morphine-induced inhibition of the twitch response. The present investigations have revealed that adenosine and related compounds reduce ACh release from the intramural chol...Continue Reading

References

Jan 21, 1977·European Journal of Pharmacology·S G McKenzieH P Bär
May 6, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·H Osswald
Nov 24, 1970·Biochimica Et Biophysica Acta·H Shimizu, J Daly
Mar 1, 1967·British Journal of Pharmacology and Chemotherapy·M D Gershon
Feb 1, 1973·Biochemical Pharmacology·S V Hopkins
Sep 1, 1969·British Journal of Pharmacology·L McInnes, J R Parratt
Oct 1, 1969·British Journal of Pharmacology·M R FennessyM J Rand
Mar 1, 1970·European Journal of Pharmacology·N KolassaW Rummel
Jan 1, 1971·European Journal of Pharmacology·N KolassaM Träm
Nov 1, 1966·British Journal of Pharmacology and Chemotherapy·A Stafford
Sep 1, 1949·British Journal of Pharmacology and Chemotherapy·H O SCHILD

❮ Previous
Next ❯

Citations

Feb 1, 1979·European Journal of Pharmacology·A L MuellerN Weiner
Jan 8, 1982·European Journal of Pharmacology·C J Moody, G Burnstock
Aug 13, 1982·European Journal of Pharmacology·M ToniniA Crema
Jul 17, 1985·European Journal of Pharmacology·W M Fu, S Y Lin-Shiau
Nov 5, 1991·European Journal of Pharmacology·E C Monteiro, J A Ribeiro
Jan 1, 1982·General Pharmacology·L P DaviesD D Jamieson
Jan 1, 1992·General Pharmacology·A CalignanoL Sorrentino
Jun 16, 2000·European Journal of Pharmacology·G HalimiR Guieu
Jun 1, 1978·British Journal of Pharmacology·C N Scholfield
Apr 1, 1979·British Journal of Pharmacology·P J Karras, R A North
Jul 1, 1986·Acta Physiologica Scandinavica·P Aas, F Fonnum
Sep 1, 1987·Acta Physiologica Scandinavica·N P Wiklund, L E Gustafsson
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Oct 14, 2008·Pharmacology & Therapeutics·Luca AntonioliCorrado Blandizzi
Mar 1, 1987·Journal of Autonomic Pharmacology·P DorigoI Maragno
Dec 1, 1988·Journal of Neurochemistry·R RubioR M Berne
Jun 1, 1980·Circulation Research·H J Granger, C P Norris
Apr 14, 1983·Nature·H O Collier, J F Tucker
May 1, 1991·Journal of Neurochemistry·B Sperlagh, E S Vizi
Mar 1, 1981·Journal of Neurochemistry·C A Briggs, J R Cooper
Mar 1, 1987·Circulation Research·J A Bevan, J E Brayden
May 1, 1980·British Journal of Pharmacology·T V Dunwiddie, B J Hoffer
Mar 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jason N Peart, Garrett J Gross

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.