PMID: 9659291Jul 11, 1998Paper

Effects of purinergic agonists on aromatase and gamma-glutamyl transpeptidase activities and on transferrin secretion in cultured Sertoli cells

The Journal of Endocrinology
S B MeroniS B Cigorraga

Abstract

To study the role of extracellular nucleosides and nucleotides in the regulation of Sertoli cells, the effects of agonists which occupy A1 and P2 purinergic receptors on aromatase and gamma-glutamyl transpeptidase (gamma-GTP) activities and on transferrin secretion were tested. Sertoli cell treatment with purinergic agonists for a prolonged period of time (72 h) resulted in an increase in aromatase activity under basal conditions. In cultures stimulated with FSH, purinergic agonists counteracted the inhibitory effect on aromatase activity that long-term treatment with FSH promoted. The effects of prolonged treatments with purinergic agonists on the other two parameters of Sertoli cell function were less pronounced. Neither gamma-GTP activity nor transferrin secretion was modified under basal conditions. On the other hand, under conditions where cell differentiation was favored by FSH treatment, reductions in gamma-GTP activity and transferrin secretion were usually observed. The results obtained in dbcAMP-stimulated cultures suggested that A1 agonists exert their regulatory function at the level of cAMP formation while P2 agonists act at a more distal point. The fact that morphological changes induced by FSH were reversed by bo...Continue Reading

Citations

Nov 11, 1999·European Journal of Pharmacology·S G BhatV Ramkumar
Sep 6, 2003·Cancer Letters·Marcia R WinkAna M O Battastini
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Nov 26, 2013·Purinergic Signalling·Geoffrey Burnstock
Aug 24, 2011·The Journal of Physiology·Sophie VeitingerMarc Spehr
Aug 21, 2010·Molecular and Cellular Endocrinology·M N GalardoS B Meroni
Aug 21, 2013·Journal of Thyroid Research·Gabriel Fernandes SilveiraAlessandra Nejar Bruno
May 20, 2015·Autonomic Neuroscience : Basic & Clinical·George I Gorodeski
Aug 31, 2016·The Journal of General Physiology·Ida Björkgren, Polina V Lishko
Aug 31, 2016·The Journal of General Physiology·David FleckMarc Spehr
Oct 11, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E A CasaliE A Bernard
Aug 5, 2017·International Journal of Molecular Sciences·Germán Domínguez-VíasIsabel Prieto
Jul 30, 2009·American Journal of Physiology. Endocrinology and Metabolism·María F RieraSelva B Cigorraga
Dec 6, 2005·Molecular and Cellular Biochemistry·Luiz Fernando de SouzaElena Aida Bernard
Sep 24, 2005·Molecular and Cellular Biochemistry·Daniel Pens GelainJosé Cláudio Fonseca Moreira
Sep 22, 2011·Archives of Biochemistry and Biophysics·Leila ZanattaFátima Regina Mena Barreto Silva

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