PMID: 12770358May 29, 2003Paper

Effects of putative diuretic factors on intracellular second messenger levels in the Malpighian tubules of Aedes aegypti

Journal of Insect Physiology
C Cady, H H. Hagedorn

Abstract

Intracellular levels of the second messengers, 3',5'-cyclic adenosine monophosphate (cAMP) and inositol 1,4,5-trisphosphate (IP(3)) were measured in the Malpighian tubules of Aedes aegypti following the in vitro application of 5-hydroxytryptamine (5-HT) and the putative mosquito diuretic peptides, Culex salinarius diuresin and mosquito leucokinins (culekinin depolarizing peptides (CDPs) I, II, III, A. aegypti leucokinin peptides (ALPs) I, II, III). The C. salinarius diuresin significantly (p<0.05) increased tubule intracellular cAMP concentrations. Treatment of tubules with either 5-HT or CDP-II resulted in significant increases in both intracellular cAMP and IP(3) concentrations. All of the mosquito leucokinins, with the exception of CDP-I, significantly stimulated intracellular IP(3) in isolated tubules. These data suggest that the mosquito leucokinins may function on the Malpighian tubules of A. aegypti by increasing the intracellular Ca(2+) levels through the release of IP(3) sensitive Ca(2+) stores. The physiological relevance of these data to the regulation of mosquito Malpighian tubule function is discussed.

References

Jan 1, 1977·Journal of Insect Physiology·H H HagedornT R Flanagan
Sep 1, 1992·Trends in Pharmacological Sciences·J Baumgold
Sep 16, 1991·Biochemical and Biophysical Research Communications·E LehmbergD A Schooley
Oct 1, 1991·Biological Chemistry Hoppe-Seyler·I KayG J Goldsworthy
Dec 31, 1991·Biochemical and Biophysical Research Communications·M B BlackburnM C Ma
Apr 12, 1991·Journal of Chromatography·G D WheelockH H Hagedorn
Sep 22, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M J Berridge
Jan 1, 1986·The Journal of Membrane Biology·M C Sekar, L E Hokin
Aug 1, 1987·The Biochemical Journal·K A Wreggett, R F Irvine
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P J Morgan, W Mordue
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K B SeamonJ W Daly
Feb 1, 1982·General and Comparative Endocrinology·J P Shapiro, H H Hagedorn
Jan 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·N AudsleyG M Coast
Jul 29, 1994·Biochemical and Biophysical Research Communications·J A Veenstra
Sep 1, 1993·Insect Biochemistry and Molecular Biology·P V Pietrantonio, S S Gill
Feb 1, 1993·The Journal of Membrane Biology·T L PannabeckerK W Beyenbach
Apr 24, 1997·Annals of the New York Academy of Sciences·T K HayesK Beyenbach
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H KataokaD A Schooley

❮ Previous
Next ❯

Citations

May 29, 2003·Journal of Insect Physiology·K W. BeyenbachM -J. Yu
Jun 27, 2012·Annals of the New York Academy of Sciences·Klaus W Beyenbach
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Ming-Jiun Yu, Klaus W Beyenbach
Mar 3, 2018·The Journal of Experimental Biology·Farwa SajadiJean-Paul V Paluzzi
Aug 20, 2005·The Journal of Experimental Biology·Geoffrey M CoastDavid A Schooley
Jul 6, 2004·The Journal of Experimental Biology·Richard C MassaroKlaus W Beyenbach

❮ Previous
Next ❯

Related Feeds

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.