PMID: 9192351May 1, 1997Paper

Effects of quaternary ammonium compounds with 0.1% sodium hydroxide on swine vesicular disease virus

The Journal of Veterinary Medical Science
J ShiraiR Seki

Abstract

The effects of quaternary ammonium compounds (QACs) with sodium hydroxide on swine vesicular disease virus (SVDV), an enterovirus were studied. Didecyldimethylammonium chloride (DDAC) with 0.1% NaOH showed a stronger effect against SVDV than other QACs with 0.1% NaOH. The effect of DDAC with 0.1% NaOH was strong at 40 degrees C. DDAC was effective against SVDV at pH values around 11.0, but not in the distilled water control. The effect of DDAC with 0.1% NaOH was already observed at 1 min after mixing of the DDAC with SVDV. Observation under an electron microscopy revealed that the probable mechanism of inactivation of DDAC with 0.1% NaOH is as follows: The virus particles were partially destroyed by 0.1% NaOH. DDAC gathered these affected particles and formed a micelle, then SVDV lost its infectivity. From these results, QACs with 0.1% NaOH are considered to be very effective against SVDV representing enteroviruses.

References

May 1, 1975·The British Veterinary Journal·J H BlackwellP D McKercher
Sep 21, 1968·Nature·L NardelliB Cartwright
Dec 15, 1973·The Veterinary Record·K A HernimanR F Sellers
Mar 1, 1995·Revue Scientifique Et Technique·P Maris
Mar 1, 1995·Revue Scientifique Et Technique·D J Jeffrey

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Citations

Jan 25, 2012·Journal of Toxicologic Pathology·Toshinori YoshidaTakanori Harada
Sep 19, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Aya OhnumaTakanori Harada
Nov 4, 2000·The Veterinary Journal·F Lin, R P Kitching
Sep 4, 2021·Journal of Medical Microbiology·Andrew D Wales, Robert H Davies

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