Effects of quercetin on proliferation and migration of human glioblastoma U251 cells

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yue LiuCai-Li Li

Abstract

Quercetin is a flavonoid that has been shown to have anti-oxidation, anti-inflammation, anti-allergic, anti-viral, and anti-cancer activities. Here, we examined the effects of quercetin on cell viability, cell cycle progression, and migration in U251 cells, a human glioblastoma cell line. We found that quercetin inhibited cell proliferation after treating cells for 24 (IC50 of 113.65μg/ml) or 48h (IC50 of 48.61μg/ml). Quercetin treatment also induced apoptosis via deregulating the expression of apoptotic genes, including Bax and Bcl-2, and arrested cell cycle at G2/M phases. We further found that quercetin impaired cell migration and invasion via downregulating the expression of matrix metallopeptidases MMP9 and MMP2. Our results provide evidences that quercetin has inhibitory effects on glioblastoma cell proliferation and invasion, and suggest a potential clinical application for glioblastoma.

References

Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J V Formica, W Regelson
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P C Hollman, M B Katan
Jan 5, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·C D ScopaA C Tsamandas
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Stella Maris RanuncoloLydia Puricelli
Apr 1, 2004·British Journal of Cancer·G La RoccaS Minafra
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Apr 29, 2006·Molecular and Cellular Biochemistry·M R VijayababuJ Arunakaran
Mar 8, 2008·Bioscience, Biotechnology, and Biochemistry·Shunsuke TanigawaDe-Xing Hou
Apr 17, 2008·Environmental Health Perspectives·Sarah M MenseHari K Bhat
Jun 27, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J M DavisJ D Gangemi
Jul 16, 2008·Molecular Aspects of Medicine·Gillian Murphy, Hideaki Nagase
Aug 21, 2008·Journal of Neuro-oncology·Camilo E FadulJeffrey J Olson
Oct 2, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Stephan C Bischoff
Oct 29, 2008·Oncogene·K W Yip, J C Reed
Nov 8, 2008·Current Opinion in Neurology·Audrey RousseauCharles Duyckaerts
Nov 15, 2008·Journal of Cellular Biochemistry·Jae-Hoon JeongYong J Lee
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roopali RoyMarsha A Moses
Feb 9, 2010·Cellular & Molecular Biology Letters·Ana FariaConceição Calhau
Sep 12, 2014·ACS Chemical Biology·Alexandra PrimikyriAndreas G Tzakos
Nov 5, 2014·Current Opinion in Neurology·Adelheid WoehrerJill S Barnholtz-Sloan
Jan 7, 2015·Nature Reviews. Clinical Oncology·David A Reardon, Patrick Y Wen
Aug 13, 2015·Current Medicinal Chemistry·Ana Filipa BritoMaria Filomena Botelho
Oct 17, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·C GzellM Foote

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Citations

Jul 25, 2018·Phytotherapy Research : PTR·Abdur RaufMohammad S Mubarak
Aug 31, 2018·PloS One·Arunotai SiriussawakulChayanan Thanakiattiwibun
Dec 1, 2018·Journal of Cellular Physiology·Raedeh SaraeiAli Hassanzadeh
Oct 17, 2019·Fundamental & Clinical Pharmacology·Cing-Yu ChenEdmund Cheung So
Dec 28, 2019·BioFactors·Erfan TavanaAmirhossein Sahebkar
Feb 16, 2020·Nutrients·Dalia M KopustinskieneJurga Bernatoniene
Apr 10, 2020·Anti-cancer Agents in Medicinal Chemistry·Serpil ÖzsoySevinç Yücecan
Dec 5, 2019·Arquivos De Gastroenterologia·Juliana Vanessa Colombo Martins-PerlesJacqueline Nelisis Zanoni
Jan 16, 2020·Current Pharmaceutical Design·Joana BickerAmílcar Falcão
Mar 11, 2020·Pharmacological Reports : PR·Mohammad SoukhtanlooAmir R Afshari
Oct 14, 2020·Interdisciplinary Sciences, Computational Life Sciences·Yi LuChujun Li
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mai KhaterHelen M I Osborn
Apr 9, 2021·Molecular and Cellular Endocrinology·Carlos Frederico Lima GonçalvesAndrea Claudia Freitas Ferreira
Dec 1, 2020·Molecular Therapy Oncolytics·Hamed Mirzaei, Michael R Hamblin
Aug 20, 2021·SAGE Open Medicine·Dejene Tolossa DebelaTsegahun Manyazewal
Aug 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rafał Paweł KampaPiotr Bednarczyk

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