Effects of quinine on K+ transport in heart mitochondria

Journal of Bioenergetics and Biomembranes
D W JungG P Brierley

Abstract

Quinine inhibits the respiration-dependent extrusion of K+ from Mg2+-depleted heart mitochondria and the passive osmotic swelling of these mitochondria in K+ and Na+ acetate at alkaline pH. These observations concur with those of Nakashima and Garlid (J. Biol. Chem. 257, 9252, 1982) using rat liver mitochondria. Quinine also inhibits the respiration-dependent contraction of heart mitochondria swollen passively in Na+ or K+ nitrate and the increment of elevated respiration associated with the extrusion of ions from these mitochondria. Quinine, at concentrations up to 0.5 mM, inhibits the respiration-dependent 42K+/K+ exchange seen in the presence of mersalyl, but higher levels of the drug produce increased membrane permeability and net K+ loss from the matrix. These results are all consistent with an inhibition of the putative mitochondrial K+/H+ antiport by quinine. However, quinine has other effects on the mitochondrial membrane, and possible alternatives to this interpretation are discussed.

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Citations

Apr 1, 1986·Journal of Bioenergetics and Biomembranes·J J DiwanT Haley
Apr 1, 1988·Journal of Bioenergetics and Biomembranes·G P Brierley, D W Jung
Apr 1, 1988·Journal of Bioenergetics and Biomembranes·G P BrierleyD W Jung
Apr 1, 1988·Journal of Bioenergetics and Biomembranes·J J DiwanC Moore
Sep 24, 2004·The Journal of Membrane Biology·P BednarczykA Szewczyk
Jul 25, 2009·Journal of Bioenergetics and Biomembranes·Sergey M Korotkov
Aug 27, 2005·Mitochondrion·Salvatore PassarellaLidia de Bari
Sep 26, 2003·Biochimica Et Biophysica Acta·Keith D Garlid, Petr Paucek
Feb 28, 1991·Biochemical and Biophysical Research Communications·G CostaJ J Diwan
Jan 1, 1987·Biochimica Et Biophysica Acta·J J Diwan
Jan 8, 2010·American Journal of Physiology. Cell Physiology·Mohammed AldakkakAmadou K S Camara
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Osvaldo Pereira, Alicia J Kowaltowski
Mar 28, 1986·Biochemical and Biophysical Research Communications·J J Diwan
May 31, 1988·Biochemical and Biophysical Research Communications·J J DiwanD R Sanadi

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