PMID: 8458036Jan 1, 1993

Effects of R-PIA, a selective A1 adenosine agonist, on haemodynamics and ischaemic arrhythmias in pigs

Cardiovascular Research
C L Wainwright, J R Parratt

Abstract

Adenosine has previously been shown to protect against ischaemia induced ventricular arrhythmias. The aim of this study was to determine whether stimulation of A1 adenosine receptors with a selective agonist also protects against arrhythmias, and to attempt to elucidate the underlying mechanisms. Large White/Welsh Landrace cross breed domestic pigs (25-40 kg) subjected to left anterior descending coronary artery occlusion were used. R-PIA [R(-)N6-(2-phenylisopropyl) adenosine; 5 micrograms.kg-1] was given prior to coronary artery occlusion and the effects on haemodynamic variables and early ischaemic arrhythmias in the absence and presence of right atrial pacing were studied. The three experimental groups were: solvent controls, n = 10; R-PIA without pacing, n = 10; R-PIA with atrial pacing, n = 10. Ex vivo assessment of platelet aggregation was also performed to determine any inhibitory effects of R-PIA on platelets. Administration of R-PIA without atrial pacing reduced the total number of ventricular ectopic beats induced by coronary occlusion, from 326(SEM 71) in controls to 121(30) (p < 0.05) and the incidence of ventricular fibrillation from 70% to 20% (p < 0.05). At the dose used, R-PIA reduced heart rate from 102(7) to 7...Continue Reading

Citations

Feb 10, 2000·European Journal of Pharmacology·H NaitoK Hashimoto
Jun 1, 1993·British Journal of Pharmacology·C L WainwrightH Van Belle
Apr 1, 1996·The Journal of Pharmacy and Pharmacology·M J HagertyK A Kane
Feb 17, 1998·Basic Research in Cardiology·F GrundA Ilebekk
May 24, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·Ersöz Gonca, Faruk Darıcı
Jan 12, 2001·Clinical and Experimental Pharmacology & Physiology·R B Rose'MeyerR J Willis

Related Concepts

Cardiac Depressants
Diastolic Blood Pressure
Pulse Rate
Myocardial Contraction
Phenylisopropyladenosine
Methyladenine Receptors
Myocardial Ischemia

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