Effects of radiation therapy on pedicled transverse rectus abdominis myocutaneous flap breast reconstruction

Annals of Plastic Surgery
G W CarlsonAlbert Losken

Abstract

Radiotherapy is being increasingly used in the treatment of breast cancer after breast conservation as well as after total mastectomy. The effect of radiation on pedicled transverse rectus abdominis myocutaneous (TRAM) flap reconstruction is examined. A retrospective review of 199 patients undergoing 232 pedicled TRAM flap reconstructions was performed to identify patients who received radiotherapy. Patients were stratified into 5 groups by the use and timing of radiation as well as the timing of the reconstruction. The overall esthetic appearances were assessed by blinded reviewers. The incidence of flap complications was 34.2% in the immediate nonirradiated group, 10.7% in the delayed nonirradiated group, 44% in the post-TRAM radiation group, 60% in the immediate pre-TRAM radiation group, and 33% in the delayed pre-TRAM radiation group (P = 0.010). Patients who had immediate TRAM flap reconstruction and did not receive radiation had a better global esthetic outcome (P < 0.001) than the other 4 groups. The esthetic outcome was similar whether radiation was administered pre- or post-TRAM flap reconstruction. Radiation therapy has a deleterious effect on the esthetic outcome of pedicled TRAM flap reconstruction whether administe...Continue Reading

References

Feb 1, 1979·International Journal of Radiation Oncology, Biology, Physics·J R HarrisS Hellman
Nov 1, 1976·The Journal of Nervous and Mental Disease·J J Bartko, W T Carpenter
Oct 1, 1986·The British Journal of Surgery·R E ManselL E Hughes
Jun 1, 1995·Plastic and Reconstructive Surgery·P A WattersonG I Taylor
Nov 5, 1997·Plastic and Reconstructive Surgery·J K WilliamsG Mackay
Dec 30, 1999·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·C D'AnielloA Carli
Apr 11, 2001·Annals of Plastic Surgery·G W CarlsonD D Denson
May 1, 2002·Annals of Plastic Surgery·Daniela Francescato VeigaJoão Lorenzo Bidart Sampaio Rocha
May 8, 2002·Plastic and Reconstructive Surgery·Nicole E Rogers, Robert J Allen

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Citations

Jul 28, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Mark V SchaverienStephen J McCulley
Aug 5, 2008·The Cancer Journal·Pierre M Chevray
Jul 3, 2010·Plastic and Reconstructive Surgery·Khayam AzzawiCharles M Malata
Mar 12, 2010·Plastic and Reconstructive Surgery·Frank P AlbinoHoward N Langstein
Oct 23, 2010·Plastic and Reconstructive Surgery·Joshua FosnotJoseph M Serletti
Oct 26, 2010·Annals of Surgical Oncology·Shelley PotterJane Blazeby
Nov 27, 2010·Journal of Cancer Survivorship : Research and Practice·Namrata S AnavekarMark W Ashton
Jul 13, 2011·Acta Oncologica·Bekka O ChristensenTine Engberg Damsgaard
Mar 25, 2016·Journal of the American College of Surgeons·Katelin B NickelMargaret A Olsen
Jun 26, 2013·Journal of the American College of Surgeons·James L MayoHugo St Hilaire
Mar 20, 2013·Clinics in Plastic Surgery·Valerie Lemaine, Colleen McCarthy
Jan 12, 2016·Journal of Surgical Oncology·Bassim El-SabawiKetan M Patel
May 15, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M El-NemrC Bourgier
Aug 17, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E MonrigalC Pomel
Jun 30, 2010·International Journal of Radiation Oncology, Biology, Physics·Tolulope A AdesiyunAbram Recht
Nov 6, 2009·Current Problems in Surgery·John T VettoArpana Naik
Sep 9, 2015·Journal of Surgical Oncology·Bassim El-SabawiKetan M Patel
Feb 19, 2015·Annals of Surgical Oncology·Saskia W M C MaassToni Zhong
Aug 30, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Judith BerbersLiesbeth J Boersma
Dec 16, 2016·Plastic and Reconstructive Surgery. Global Open·Sergi Barrera-OchoaRoberto Velez
Aug 23, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Johanna H YunAmber G Orman
May 28, 2011·Plastic and Reconstructive Surgery·Joseph M SerlettiLouis P Bucky
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Henry M KuererRobert W Mutter
Sep 28, 2016·Plastic and Reconstructive Surgery·Thiago B de AraujoYoon S Chun
Nov 6, 2012·Annals of Plastic Surgery·Yoon S ChunJulian J Pribaz
Aug 26, 2010·Expert Review of Anticancer Therapy·David A SieberKevin V Albuquerque
May 17, 2017·Plastic and Reconstructive Surgery. Global Open·Merisa L PiperHani Sbitany
Jan 12, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Korri S HershenhouseKetan M Patel
Jul 25, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J P M O'DonnellN M McInerney

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