PMID: 8643274Apr 1, 1996Paper

Effects of radiation therapy on reconstruction of mandibular defects with a titanium reconstruction plate

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
D W KlotchA Slater-Haase

Abstract

Titanium fixation plates are commonly used in reconstruction of mandibular defects resulting from tumor resections in head and neck surgery. The effects of radiation therapy on the interface of bone, plate, and soft tissue were examined in this in vivo study. Four conditioned beagles had 1-cm segmental mandibular defects that were reconstructed with titanium plates. Two of the four also had placement of vascularized bone grafts. Healing was evaluated with or without postoperative radiotherapy. After collection of tissues using histologic methods and analysis with energy-dispersive spectroscopy, we found that the effects of radiation on bone-plate and bone-screw interfaces is minimal. Although radiation decreased the bone density and the rate of bone repair at the bone-screw interface, this did not appear to affect stability of the plate repair or the viability of bone tissue.

References

Jun 1, 1990·Plastic and Reconstructive Surgery·J H Phillips, B A Rahn
Oct 1, 1990·American Journal of Surgery·D W KlotchL Kuhn
Oct 1, 1987·American Journal of Surgery·D W Klotch, J Prein
Feb 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J B EpsteinP Stevenson-Moore
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R R PelkerA Doganis

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Citations

Jul 29, 2003·American Journal of Otolaryngology·Francisco V de Mello-FilhoCatherine E Miles
Jan 9, 1998·International Journal of Radiation Oncology, Biology, Physics·A S AllalJ M Kurtz
Nov 21, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Alexis B OlssonSanjay P Reddi
Mar 10, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S P Hao
Jul 20, 2018·Clinical Orthopaedics and Related Research·Yongren WuVincent D Pellegrini

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