Effects of Radioactive Iodine Therapy on Ovarian Reserve: A Prospective Pilot Study

Thyroid : Official Journal of the American Thyroid Association
Berna EvranosBekir Cakir

Abstract

Background: Thyroid carcinoma is the most common endocrine malignancy. Surgery is the standard therapeutic approach for patients with differentiated thyroid carcinoma (DTC), followed by radioiodine (RAI) therapy if indicated. For women with DTC, the effects of RAI therapy on gonadal and reproductive function are an important consideration. This study aimed to evaluate the effects of RAI therapy on ovarian function. Methods: A total of 33 premenopausal women were enrolled in this study. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, and anti-Müllerian hormone (AMH) levels during the early follicular phase were measured before and 3, 6, and 12 months after RAI therapy. The Friedman and Wilcoxon tests were used to detect changes in FSH, AMH, LH, and estradiol levels induced by RAI therapy over time. Results: The patients' ages ranged from 21 to 38 years, with a mean age of 31.15 ± 4.83 years. The median follow-up was 19 months (range 4-26 months). The median AMH levels were 3.25 ng/mL (range 0.32-17.42 ng/mL), 1 ng/mL (range 0.01-3.93 ng/mL), 1.13 ng/mL (range 0.08-6.12 ng/mL), and 1.37 ng/mL (range 0.09-6.1 ng/mL) before and at 3, 6, and 12 months after RAI therapy, respectively. The median FS...Continue Reading

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Citations

Feb 1, 2019·Thyroid : Official Journal of the American Thyroid Association·Iris YaishKaren M Tordjman
May 9, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Angelo CagnacciAnne Gompel
Jan 7, 2020·Thyroid : Official Journal of the American Thyroid Association·Chrysoula Dosiou
Jan 14, 2020·Thyroid : Official Journal of the American Thyroid Association·Evert F S van VelsenRobin P Peeters
Feb 23, 2020·Thyroid : Official Journal of the American Thyroid Association·Marloes NiesThera P Links
Aug 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Loes M E Moolhuijsen, Jenny A Visser
Apr 10, 2020·The Journal of Clinical Endocrinology and Metabolism·H Irene SuLoki Natarajan
Oct 28, 2019·Thyroid : Official Journal of the American Thyroid Association·Meng RaoLi Tang
Oct 6, 2020·Thyroid : Official Journal of the American Thyroid Association·Marceline W PiekIris M C van der Ploeg
Nov 4, 2020·The Journal of Clinical Endocrinology and Metabolism·Alexa C O MedicaH Irene Su
Oct 4, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Giuliano MarianiH William Strauss

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS Statistics

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