Effects of radiotherapy on different histopathological types of rectal carcinoma

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
N SengulM Berho

Abstract

Down staging by pre-operative chemoradiotherapy is currently considered part of the standard therapeutic approach to rectal carcinoma. The aim of this study was to assess the response to chemoradiotherapy of different histopathological types of rectal carcinoma with emphasis on the mucinous variant. Between 1997 and 2002, 71 patients who received pre-operative chemoradiotherapy followed by surgery for rectal carcinoma were enrolled in the study. Staging of the rectal carcinoma was performed according to transrectal ultrasound findings (TN score) prior to the chemoradiotherapy. The chemoradiotherapy was followed by radical resection with mesorectal excision. All surgical specimens were examined by a single pathologist (MB). Pathological TN staging was assessed and tumour regression was graded according to a standard method (TRG1, complete response - TRG5 no response). Tumours were classified as mucinous or nonmucinous according to pre- and post-operative biopsy and specimen histopathological types. TN score change and TRG differences between groups were assessed. Tumour regression was seen after chemoradiotherapy in 94.4% of the patients, while in 5.6% of the patients no response was found. The change in TN score and TRG were co...Continue Reading

References

Apr 1, 1976·Cancer·D A Symonds, A L Vickery
Dec 15, 1987·Cancer·B D MinskyJ T Chaffey
Jan 1, 1997·International Journal of Colorectal Disease·O DworakA Hoffmann
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·R WagmanP P Paty
Dec 30, 1998·International Journal of Radiation Oncology, Biology, Physics·M C Kaminsky-ForrettP Bey
Oct 3, 1999·The British Journal of Surgery·J M WheelerN J Mortensen
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·N A JanjanJ Skibber
Aug 17, 2000·JAMA : the Journal of the American Medical Association·C CammàM Cottone
Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Jan 11, 2002·The New England Journal of Medicine·Alan P Meagher
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A M MarijnenUNKNOWN Cooperative Investigators of the Dutch Colorectal Cancer Group
Jun 26, 2002·The Journal of Pathology·Iris D NagtegaalUNKNOWN Pathology Review Committee
Jan 25, 2003·Journal of Computer Assisted Tomography·Myeong-Jin KimWon Ho Kim
Apr 16, 2005·The American Journal of Surgical Pathology·Anne RullierEric Rullier

❮ Previous
Next ❯

Citations

Feb 27, 2010·Inflammatory Bowel Diseases·Igors IesalnieksHans J Schlitt
Sep 24, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N HugenJ H W de Wilt
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Andrea Ambrosini-SpaltroMaria P Foschini
Feb 25, 2011·Annals of Surgical Oncology·Ui Sup ShinJin Cheon Kim
Dec 12, 2013·Techniques in Coloproctology·M ChandG Brown
Jan 21, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stanley K T YuGina Brown
Sep 2, 2015·Nature Reviews. Clinical Oncology·Niek HugenIris D Nagtegaal
Sep 24, 2015·International Journal of Surgery·Khaled M MadboulyWaleed Omar
Nov 5, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Cheol Min KangJin Cheon Kim
Nov 29, 2012·Journal of Magnetic Resonance Imaging : JMRI·Katja OberholzerDüber Christoph
Jul 3, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S AnwarD Sebag-Montefiore
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jing-Xiang ChenGui-Yin Sun
Jan 8, 2015·Annals of Surgical Oncology·Niek HugenIris D Nagtegaal
Apr 21, 2016·Surgery Today·Hirofumi SasakiMotoi Uchino
Jan 18, 2011·International Journal of Radiation Oncology, Biology, Physics·Katja OberholzerHeinz Schmidberger
May 16, 2017·Annals of Coloproctology·Sare HosseiniMohammad Mohammadianpanah
Jun 28, 2017·Journal of Clinical Gastroenterology·Christian GalataKaroline Horisberger
Jul 13, 2018·Expert Review of Gastroenterology & Hepatology·Takayuki YamamotoRemo Panaccione
Mar 30, 2019·Cancer Communications·Cong LuoWei Wu
Apr 18, 2019·AJR. American Journal of Roentgenology·Amelia M WnorowskiMeghan G Lubner
Apr 18, 2019·Abdominal Radiology·Natally HorvatIva Petkovska
Sep 29, 2020·Frontiers in Oncology·Ian S ReynoldsSimon J Furney
Apr 4, 2021·Cancers·Emer O'ConnellJochen H M Prehn
Aug 24, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Junqin ZhangShudong Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.