Effects of raloxifene and estrogen on bioactive IGF1 in GH-deficient women

European Journal of Endocrinology
Vita BirznieceJan Frystyk

Abstract

GH action is attenuated by estrogens and selective estrogen receptor modulators (SERMs) administered orally. During GH therapy in hypopituitary women, co-treatment with raloxifene, a SERM, induced a smaller gain in lean body mass (LBM) compared with estrogen, despite an equal reduction in IGF1. As a higher IGF-binding protein-3 (IGFBP3) level was observed with raloxifene co-treatment, we hypothesize that an increase in IGFBP3 reduced IGF1 bioactivity causing the attenuated anabolic effect. To assess the effects of 17β-estradiol (E₂) and raloxifene on bioactive IGF1. In study 1, 12 GH-deficient (GHD) women were randomized to raloxifene 120 mg/day or E₂ 4 mg/day for 1 month. In study 2, 16 GHD women were randomized to 1 month GH treatment alone (0.5 mg/day) and in combination with raloxifene (60 mg/day) or E₂ (2 mg/day). We measured bioactive IGF1, immunoreactive IGF1 and IGF2, and IGFBP3 immunoreactivity and fragmentation. Raloxifene and estrogen suppressed (P<0.05) total IGF1 equally in GHD and GH-replaced hypopituitary women. In GHD patients, neither raloxifene nor estrogen affected bioactive IGF1. GH significantly increased IGF1 bioactivity, an effect attenuated by co-treatment with raloxifene (Δ -23 ± 7%, P<0.01) and estroge...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 1, 1986·The Journal of Clinical Investigation·R C Baxter, J L Martin
Apr 30, 1994·Lancet·D M HoffmanK K Ho
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·S YakarD LeRoith
Mar 11, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·E M ZimmermannP K Lund
Jan 5, 2002·Breast Cancer Research and Treatment·B BonanniA Decensi
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Josef V SilhaLiam J Murphy
Feb 27, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jian-Wen ChenJan Frystyk
Nov 4, 2004·The Journal of Clinical Endocrinology and Metabolism·Helena K GleesonStephen M Shalet
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Christina A HedmanHans J Arnqvist
Mar 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S I HelleP E Lønning
Apr 28, 2005·The Journal of Clinical Endocrinology and Metabolism·James GibneyKen K Y Ho
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Sophie S Y ChanRobert C Baxter
Apr 17, 2008·The Journal of Clinical Endocrinology and Metabolism·M P BrugtsJ A M J L Janssen
Jan 15, 2009·American Journal of Physiology. Endocrinology and Metabolism·Sophie S Y ChanRobert C Baxter
Mar 13, 2009·American Journal of Physiology. Cell Physiology·Paulette M Yamada, Kuk-Wha Lee
May 30, 2009·Endocrine Reviews·Sherryline Jogie-BrahimYoungman Oh
Mar 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Vita BirznieceKen K Y Ho
Sep 8, 2011·Growth Factors·Janet L Martin, Robert C Baxter
Dec 14, 2011·Domestic Animal Endocrinology·J Frystyk
Dec 16, 2011·The Journal of Clinical Endocrinology and Metabolism·Vita BirznieceKen K Y Ho
Feb 1, 2012·Nature Reviews. Endocrinology·Vita Birzniece, Ken K Y Ho

❮ Previous
Next ❯

Citations

Oct 28, 2016·Endocrine·Felipe H DuarteMarcello D Bronstein
Sep 26, 2017·The Journal of Clinical Endocrinology and Metabolism·Nilani RamshankerJan Frystyk
Sep 8, 2019·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Joseph A M J L JanssenMichael P Brugts
Apr 22, 2018·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Laura E DichtelKaren K Miller
Aug 14, 2021·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Yan SunLing Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cleveland Clinic Journal of Medicine
A A LicataMichael W Draper
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
M D Whitaker
© 2021 Meta ULC. All rights reserved