Effects of ramp-up of inspired airflow on in vitro aerosol dose delivery performance for certain dry powder inhalers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Keith Ung, Hak-Kim Chan

Abstract

This study investigated the effect of airflow ramp-up on the dose delivery performance of seven dry powder inhalers, covering a broad range of powder formulations and powder dispersion mechanisms. In vitro performance tests were performed at a target pressure drop of 4kPa, using two inspiratory flow ramp-up conditions, representing slow and fast ramp-up of airflow, respectively. The fluidization of bulk powder and aerosol clearance from the inhaler was assessed by laser photometer evaluation of aerosol emission kinetics and measurement of the delivered dose (DD). The quality of aerosol dispersion (i.e. de-agglomeration) and associated lung targeting performance was assessed by measuring the total lung dose (TLD) using the Alberta idealized mouth-throat model. The ratio of DD and TLD under slow/fast ramp conditions was used as a metric to rank-order flow ramp effects. Test results show that the delivered dose is relatively unaffected by flow ramp (DD ratio ~1 for all dry powder inhalers). In contrast, the total lung dose showed significantly more variation as a function of flow ramp and inhaler type. Engineered (spray dried) powder formulations were associated with relatively high TLD (>50% of nominal dose) compared to lactose b...Continue Reading

References

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Citations

Oct 25, 2016·International Journal of Pharmaceutics·Michael Y YangHak-Kim Chan
Oct 16, 2016·Pharmaceutical Research·Jeffry Weers, Andy Clark
Oct 16, 2019·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Andrew R ClarkRajiv Dhand
Dec 7, 2019·Therapeutic Advances in Respiratory Disease·Federico LavoriniAnders Løkke
Nov 5, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Tetsuri KondoShigeto Horiuchi
Mar 27, 2021·Clinical Drug Investigation·Mathieu MolimardIvan Nikolaev
Apr 21, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Agata DoroszArkadiusz Moskal
Oct 13, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Tetsuri KondoShigeto Horiuchi

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