PMID: 11605931Oct 19, 2001Paper

Effects of rapacuronium on respiratory function during general anesthesia: a comparison with cis-atracurium

Anesthesiology
J D TobiasG Johnson

Abstract

With its introduction for widespread clinical use, there has been an increase in reports of bronchospasm related to the administration of rapacuronium. As it is commonly used for rapid sequence intubation, it has been suggested that these effects may be related to an inadequate depth of anesthesia. The current study examines the airway effects of rapacuronium in tracheally intubated, anesthetized adults. Endotracheal intubation was accomplished without the use of neuromuscular blocking agents. Dynamic compliance, tidal volume, peak inspiratory flow rate, peak expiratory flow rate, and peak inflating pressure were measured after administration of either rapacuronium (1.5 mg/kg) or cis-atracurium (0.2 mg/kg) to 20 adult patients (10 received rapacuronium and 10 received cis-atracurium) anesthetized with propofol-remifentanil. Statistically significant increases in peak inflating pressure (22 +/- 6 to 28 +/- 9 cm H2O, P = 0.0012) and decreases in dynamic compliance (108 +/- 43 to 77 +/- 41 ml/cm H2O, P = 0.0001), peak inspiratory flow rate (0.43 +/- 0.11 to 0.39 +/- 0.09 l/s, P = 0.0062), peak expiratory flow rate (0.67 +/- 0.10 to 0.59 +/- 0.09 l/s, P = 0.0015), and tidal volume (744 +/- 152 to 647 +/- 135 ml, P = 0.0293) occurre...Continue Reading

References

Feb 1, 1982·Anesthesiology·C A HirshmanH Downes
Jun 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M SullivanG D Hill
Jul 6, 1993·European Journal of Pharmacology·C M PedersenJ E Nielsen-Kudsk
Feb 16, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B W BrandomM E Lloyd

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Citations

Apr 29, 2006·American Journal of Respiratory and Critical Care Medicine·Ettore CrimiArthur S Slutsky
Mar 24, 2006·Southern Medical Journal·Joseph D Tobias
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Sep 18, 2018·Anesthesia and Analgesia·Maximilian S SchaeferTanja Astrid Meyer-Treschan
Mar 27, 2003·Anesthesiology·Edmund JoosteCharles W Emala

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