PMID: 11331561May 2, 2001Paper

Effects of rapid tryptophan depletion on brain 5-HT(2) receptors: a PET study

The British Journal of Psychiatry : the Journal of Mental Science
Lakshmi N YathamT J Ruth


The mechanism by which rapid tryptophan depletion (RTD) paradigm induces depressive relapse in recently remitted patients with depression is unknown. To determine the effects of RTD on brain 5-HT(2) receptors using positron emission tomography (PET) and (18)F-labelled setoperone. Ten healthy women under went two PET scans. Each scan was done 5 h after the ingestion of either a balanced or a tryptophan-deficient amino acid mixture, and the two test sessions were separated by at least 5 days. The RTD decreased plasma free tryptophan levels significantly but it had no significant effects on mood. Subjects showed a significant decrease in brain 5-HT(2) receptor binding in various cortical regions following the RTD session. When taken with the evidence that antidepressant treatment is associated with a decrease in brain 5-HT(2) receptors, these findings suggest that a decrease in 5-HT(2) binding following RTD might be an adaptive response that provides protection against depressive symptoms.


Dec 1, 1992·Journal of Autism and Developmental Disorders·F R VolkmarD J Cohen
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Jan 1, 1990·Annals of the New York Academy of Sciences·J E Leysen, P J Pauwels
Jan 1, 1986·Annals of the New York Academy of Sciences·K J Kellar, C A Stockmeier
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A BreierD Pickar
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S NishizawaM Diksic
Sep 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M LaruelleR B Innis
Oct 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J G Hensler, K A Truett
Mar 31, 1999·The Australasian Journal of Dermatology·D C Hill, A A Gramp

❮ Previous
Next ❯


May 1, 2001·Yeast·C CompagnoD Porro
Feb 5, 2002·European Archives of Psychiatry and Clinical Neuroscience·H Dhaenen
Jul 11, 2006·Psychopharmacology·Paul P AllenPhilip K McGuire
Mar 22, 2007·Psychopharmacology·Paolo Fusar-PoliPhilip K McGuire
Sep 29, 2011·Amino Acids·Anne SaulinRupert Lanzenberger
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Justin H G WilliamsStephen Pechey
Jul 25, 2009·Social Cognitive and Affective Neuroscience·Lihong WangScott A Huettel
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simon N Young
Jul 6, 2005·The Australian and New Zealand Journal of Psychiatry·Sean D HoodDavid J Nutt
Jun 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Lakshmi N YathamThomas J Ruth
Oct 31, 2013·Neurochemical Research·Haipeng LiuPeng Xie
Nov 29, 2002·Human Psychopharmacology·Esther Gómez-GilGinés Escolar
Apr 17, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Natalia JaworskaVerner Knott
Jul 29, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Louise M PatersonGitte M Knudsen
Sep 18, 2007·Human Psychopharmacology·Christine NorraHelmut Buchner
Jul 26, 2006·Pharmacotherapy·Megan J Ehret, Gary M Levin
May 29, 2009·The European Journal of Neuroscience·H-P Landolt, R Wehrle
Feb 15, 2005·Psychiatry Research·Seppo KähkönenJyrki Ahveninen
Apr 30, 2015·Psychopharmacology·Sjoerd J FinnemaSarah Grimwood
Apr 14, 2005·The Psychiatric Clinics of North America·Lakshmi N Yatham
Jul 6, 2011·The International Journal of Neuropsychopharmacology·Mei-See ManAngela C Roberts
Sep 8, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Chiara FabbriAlessandro Serretti
Sep 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yvette I ShelineStephen M Moerlein
Dec 4, 2003·Molecular Psychiatry·L BooijW J Riedel
Jan 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tilman HenschBurkhard Brocke

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

The British Journal of Nutrition
Michiel A van NieuwenhovenRobert-Jan M Brummer
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Peter S Talbot, Stephen J Cooper
© 2021 Meta ULC. All rights reserved