Effects of real and simulated microgravity on response of sympathoadrenal system to various stress stimuli

Annals of the New York Academy of Sciences
L MachoR Kvetnansky

Abstract

Changes in plasma levels of epinephrine (EPI) and norepinephrine (NE) were investigated in humans exposed to physical exercise (WL), to psychic stressor (mental arithmetic test, MAT), and to oral glucose administration (oGTT) before and during a stay in microgravity (real space flight, SF) or in simulated microgravity (head-down bed rest, HDBR). A permanent cannula inserted into the cubital vein and a special appliance, Plasma-03, were used for blood collection, plasma separation, and freezing of samples during SF. Plasma EPI, NE, dihydroxyphenylglycol (DHPG), and dihydroxyphenylalanine (DOPA) levels were measured by the high-pressure liquid chromatography (HPLC) method. Basal plasma EPI, NE, DHPG, and DOPA levels were found within the range of control values during SF. Preflight WL produced high increase in plasma NE and moderate elevation of plasma EPI, DHPG, and DOPA levels. Exaggerated exercise induced increases in plasma NE, DHPG, EPI, and DOPA levels were demonstrated in real microgravity. A return to preflight responses of sympathoadrenal system was seen after the landing. Plasma EPI, NE, and DHPG responses to MAT were relatively small, but increased during SF. During the oGTT the plasma EPI levels were slightly reduced ...Continue Reading

References

Feb 1, 1994·The Clinical Investigator·A I GrigorievD V Vorobiev
Feb 8, 2000·Advances in Space Biology and Medicine·F Strollo
Jan 1, 1988·Acta Astronautica·C S LeachN M Cintrón
Apr 25, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L KsinantovaM Vigas
Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·L MachoR Kvetnansky
Jul 9, 2004·Annals of the New York Academy of Sciences·Lucia KsinantováRichard Kvetnansky

❮ Previous
Next ❯

Citations

Jun 26, 2013·Fiziologiia cheloveka·A I Grigor'ev, V B Noskov
Jul 21, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Barbara CancianiSara Tavella
Nov 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·André E AubertOmer Van den Bergh
Dec 6, 2019·Archives of Oral Biology·Arthur R HandMaija I Mednieks

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
R KvetnanskyM Vigas
Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
R KvetnanskyL Macho
Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
L MachoR Kvetnansky
© 2022 Meta ULC. All rights reserved