Effects of rebamipide, a novel anti-ulcer agent, on gastric mucosal injury induced by platelet-activating factor in rats

Digestive Diseases and Sciences
S KokuraM Kondo

Abstract

We examined the role of gastric mucosal blood flow, lipid peroxidation, and neutrophil accumulation mediated by platelet-activating factor in the protective effect of rebamipide against gastric mucosal injury in rats. The intravenous injection of platelet-activating factor induced hyperemia and hemorrhagic erosions in rat stomachs. Rebamipide did not affect the decrease in the gastric mucosal blood flow induced by platelet-activating factor. The increase in gastric injury score after platelet-activating factor injection and the increase in thiobarbituric acid-reactive substances were significantly inhibited by the administration of rebamipide. The gastric injury score was closely correlated with the accumulation of lipid peroxides. Tissue-associated myeloperoxidase activity in the gastric mucosa significantly increased after platelet activating factor injection; this increase was not influenced by rebamipide treatment. The protective effect of rebamipide against the platelet-activiting factor-induced gastric mucosal injury may be due to direct inhibition of lipid peroxidation or scavenging of oxygen radicals that initiate lipid peroxidation.

Citations

Jun 27, 2000·Scandinavian Journal of Gastroenterology·T Matysiak-BudnikF Mégraud
Sep 27, 2005·Digestive Diseases and Sciences·Kazuhiro KatadaToshikazu Yoshikawa
Aug 20, 2003·Alimentary Pharmacology & Therapeutics·T JohM Itoh
Aug 20, 2003·Alimentary Pharmacology & Therapeutics·M KojimaK Fujimoto
Sep 27, 2005·Digestive Diseases and Sciences·Toshio WatanabeTetsuo Arakawa
Aug 20, 2003·Alimentary Pharmacology & Therapeutics·T Matysiak-BudnikF Mégraud

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