Effects of rebamipide on nephrotoxicity associated with selected NSAIDs in rats

European Journal of Pharmacology
Robert C WoodSam Harirforoosh

Abstract

Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is primarily limited by renal and gastrointestinal adverse effects. Rebamipide suppresses gastric mucosal injury when administered with NSAIDs. This study aimed to determine rebamipide's influence upon renal effects following concomitant use with celecoxib or diclofenac. On day 0, rats were randomly divided into 6 groups (n≥6). On days 1 and 2, three groups received placebo and three groups were administered rebamipide (30 mg/kg) twice daily. On day 3, the rats treated with placebo received another dose of placebo and ten minutes later a single dose of celecoxib (40 mg/kg), diclofenac (10mg/kg), or placebo, respectively. The rats treated with rebamipide received one more dose of rebamipide and ten minutes later one single dose of celecoxib, diclofenac, or placebo, respectively. Urine and blood samples were collected on days 0, 2, and 3. Sodium and potassium excretion rates decreased significantly in the rats treated with celecoxib, diclofenac, rebamipide plus celecoxib, or rebamipide plus diclofenac on day 3. Blood urea nitrogen (BUN) levels significantly increased in placebo plus diclofenac and rebamipide plus diclofenac groups on day 3. Comparing the two groups, the levels ...Continue Reading

References

Nov 1, 1982·Digestive Diseases and Sciences·S J KonturekA Dembińska-Kieć
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·K SeibertP Isakson
Nov 1, 1993·Archives of Family Medicine·B Kaplan, R A Swain
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·M D Murray, D C Brater
Aug 1, 1996·The American Journal of the Medical Sciences·F G DelrioD Grob
Nov 1, 2001·Journal of Gastroenterology and Hepatology·H MizoguchiK Takeuchi
Jun 26, 2002·Kidney International·Won K HanJoseph V Bonventre
Feb 26, 2003·Immunology Letters·Joseph E DinchukJames M Trzaskos
Oct 25, 2003·Toxicology and Applied Pharmacology·Juliette L LeeMohammad Athar
Mar 11, 2005·Canadian Journal of Physiology and Pharmacology·Sam Harirforoosh, Fakhreddin Jamali
Aug 9, 2005·Current Medical Research and Opinion·Elliot V HershPaul A Moore
Sep 22, 2005·American Journal of Physiology. Renal Physiology·Vishal S VaidyaJoseph V Bonventre
Sep 27, 2005·Digestive Diseases and Sciences·Tetsuo ArakawaAndrzej S Tarnawski
Aug 10, 2006·American Journal of Physiology. Renal Physiology·Martin H de BorstHarry van Goor
Sep 28, 2006·Clinical and Experimental Pharmacology & Physiology·Sam HarirforooshFakhreddin Jamali
Dec 16, 2006·Digestive Diseases and Sciences·Tetsuya TanigawaAndrzej S Tarnawski
Nov 9, 2007·Annual Review of Physiology·Chuan-Ming Hao, Matthew D Breyer
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·Christoph BrochhausenCharles James Kirkpatrick
Apr 8, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Max SieberAngela Mally
Oct 17, 2009·Expert Opinion on Drug Safety·Sam Harirforoosh, Fakhreddin Jamali
Feb 2, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dana HoffmannAngela Mally
Feb 6, 2010·Biochemical Pharmacology·Tomoaki IshiharaTohru Mizushima
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Yogesh BaravaliaSumitra Chanda

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Citations

Dec 18, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dustin L CooperSam Harirforoosh
Oct 7, 2015·Journal of Toxicologic Pathology·Derek E MurrellSam Harirforoosh

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