Effects of recombinant gonadotropin hormones on the expression of vitellogenin, gonadotropin subunits and gonadotropin receptors in cinnamon clownfish, Amphiprion melanopus

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Na Na KimCheol Young Choi

Abstract

Gonadotropins (GTHs) are the key regulators of reproduction in vertebrates. The present study investigated autoregulatory effects of gonadotropins, using recombinant FSH (rFSH) and LH (rLH) in cinnamon clownfish (Amphiprion melanopus). Experiments were carried out to investigate the actions of cinnamon clownfish rFSH and rLH on expression of GTH subunits, GTH receptors, and vitellogenin (Vtg) mRNA in vivo and in vitro. Plasma estradiol-17β (E(2)) level was also measured in immature fish following treatments with rFSH and rLH. The results demonstrate increasing levels of GTH subunits, GTH-receptors, Vtg mRNA levels, as well as plasma E(2) levels following injection with rFSH and rLH. The findings support the hypothesis that LH and FSH stimulate reproduction, in part, by autoregulatory mechanisms leading to upregulation of GTH receptors and GTH hormone production in cinnamon clownfish. The results provide a framework for better understanding of the mechanisms of GTH-mediated control of reproduction in cinnamon clownfish and other vertebrates.

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Dec 9, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Kwang Wook AnCheol Young Choi
Apr 28, 2009·General and Comparative Endocrinology·Yonathan ZoharOlivier Kah
Jan 13, 2010·General and Comparative Endocrinology·Makito KobayashiYoung Chang Sohn
Mar 30, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kwang Wook AnCheol Young Choi
Nov 1, 2011·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Na Na KimCheol Young Choi

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Citations

Aug 26, 2014·Fish Physiology and Biochemistry·Shrabanti SarkarPanchanan Nath
Dec 3, 2014·General and Comparative Endocrinology·François ChauvignéJoan Cerdà
Dec 17, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Young Jae Choi, Cheol Young Choi
Aug 21, 2016·Molecular Reproduction and Development·Hui LiuNeil J Gemmell
Jul 21, 2020·General and Comparative Endocrinology·G MolésA Gómez

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