Effects of recombinant granulocyte colony-stimulating factor on Staphylococcus aureus mastitis in lactating dairy cows.

Journal of Dairy Science
S C NickersonJ L Watts

Abstract

The in vivo effects of recombinant human granulocyte colony-stimulating factor on blood and milk leukocytes in dairy cows was examined. A 2-fold increase in peripheral white blood cell counts was observed by d 5 of treatment and peaked on d 12 with values 3-fold those of controls. Counts remained elevated above pretreatment values during the treatment period, then returned to normal by d 23 of the trial. Differential white blood cell counts demonstrated that neutrophils predominated (73.8%) in treated cows versus controls (22.1%) during the treatment period. Immediately prior to experimental challenge with Staphylococcus aureus, milk SCC were 582 x 10(3) and 261 x 10(3)/ml, and percentages milk neutrophils were 64.4 and 45.3, respectively, in treated and control cows. After challenge, a 46.7% reduction in new infections was observed in quarters of treated cows compared with controls. Recombinant human granulocyte colony-stimulating factor was a granulopoietic growth and differentiation factor in the cow, and the resulting leukocytosis into the mammary gland may have been protective against experimental bacterial challenge.

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Citations

Oct 23, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·S HuK P Waller
Aug 1, 1997·Journal of Dairy Science·L M SordilloD DeRosa
May 16, 2001·Journal of Dairy Science·J A RothM Weighner
Feb 1, 1994·Journal of Dairy Science·M E Kehrli, D E Shuster
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Aug 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·S H Hu, A F Du
Jan 1, 2014·Journal of Veterinary Medicine·Mohamed Ezzat AlnakipJorge Barros-Velázquez
Apr 10, 2003·The Veterinary Clinics of North America. Food Animal Practice·Jeanne L Burton, Ronald J Erskine

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