Effects of Recombinant Human Bone Morphogenetic Protein-2 Dose and Ceramic Composition on New Bone Formation and Space Maintenance in a Canine Mandibular Ridge Saddle Defect Model

Tissue Engineering. Part a
Anne D TalleyScott Guelcher

Abstract

Treatment of mandibular osseous defects is a significant clinical challenge. Maintenance of the height and width of the mandibular ridge is essential for placement of dental implants and restoration of normal dentition. While guided bone regeneration using protective membranes is an effective strategy for maintaining the anatomic contour of the ridge and promoting new bone formation, complications have been reported, including wound failure, seroma, and graft exposure leading to infection. In this study, we investigated injectable low-viscosity (LV) polyurethane/ceramic composites augmented with 100 μg/mL (low) or 400 μg/mL (high) recombinant human bone morphogenetic protein-2 (rhBMP-2) as space-maintaining bone grafts in a canine mandibular ridge saddle defect model. LV grafts were injected as a reactive paste that set in 5-10 min to form a solid porous composite with bulk modulus exceeding 1 MPa. We hypothesized that compression-resistant LV grafts would enhance new bone formation and maintain the anatomic contour of the mandibular ridge without the use of protective membranes. At the rhBMP-2 dose recommended for the absorbable collagen sponge carrier in dogs (400 μg/mL), LV grafts maintained the width and height of the host ...Continue Reading

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Citations

Oct 30, 2016·BoneKEy Reports·Ushashi DadwalMichaela R Reagan
Jan 30, 2018·Tissue Engineering. Part a·Runheng LiuZhuofan Chen
Sep 29, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Patricia CarlislePamela R BrownBaer
Nov 7, 2018·Tissue Engineering. Part a·Madison A P McGoughScott A Guelcher
Aug 11, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Anne D TalleyScott A Guelcher
Jun 15, 2021·Minerva Dental and Oral Science·Gabriele CervinoLuca Fiorillo
Jul 25, 2021·Materials·Lauren A BollerScott A Guelcher

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

ImageJ
SCANCO Medical μCT
Metamorph

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