Effects of recombinant murine leptin on steroid secretion of dispersed rat adrenocortical cells

The Journal of Steroid Biochemistry and Molecular Biology
L K MalendowiczA Markowska

Abstract

Leptin is a peptide secreted by adipose tissue, which regulates satiety, metabolic rate, and thermogenesis. Since corticosteroids regulate the mass of adipose tissue, and leptin synthesis and secretion by adipocytes, we have examined whether leptin in turn is able to directly affect adrenal steroid secretion. Recombinant murine leptin was found to increase basal aldosterone and corticosterone production by dispersed rat zona glomerulosa and zona fasciculata-reticularis cells, respectively. In contrast, leptin did not affect maximally ACTH (10(-9) M)-stimulated steroid secretion. These findings, coupled with the recent observation that leptin is able to stimulate hypothalamo-pituitary CRH-ACTH system, may indicate a role for leptin as a regulator of adrenocortical function in the rat.

References

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Citations

Dec 31, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Ludwik K MalendowiczMariola Majchrzak
Jan 6, 2000·The Journal of Steroid Biochemistry and Molecular Biology·L K MalendowiczG G Nussdorfer
Apr 3, 2001·European Journal of Clinical Investigation·A Glasow, S R Bornstein
Aug 15, 2000·Annual Review of Nutrition·C A BaileR J Martin
Apr 1, 2014·European Journal of Medicinal Chemistry·Antonella LeggioAngelo Liguori
Apr 9, 2014·Journal of Physiology and Biochemistry·K FarhanaH J Singh
Jun 3, 2016·The Journal of Endocrinology·Ding Xie, Wendy B Bollag
Aug 27, 1998·Hypertension·S R Bornstein, D J Torpy
Aug 20, 2005·Journal of Cellular Physiology·Cecilia Garofalo, Eva Surmacz
Sep 17, 1998·Endocrine Research·L K MalendowiczK W Nowak
Dec 19, 2014·American Journal of Physiology. Renal Physiology·Mitsuhiro Nishimoto, Toshiro Fujita
Mar 26, 2021·Human Reproduction Update·Sebastião Freitas de MedeirosRobert John Norman

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