Effects of reduced coronary flow reserve on left ventricular function in type 2 diabetes

Diabetes Research and Clinical Practice
Osamu YonahaNigishi Hotta

Abstract

Diabetic patients without clinical evidence of cardiovascular disease may develop left ventricular (LV) dysfunction. The present study was designed to test the hypothesis that coronary microvascular dysfunction affects LV function in type 2 diabetic patients. The study subjects were 20 type 2 diabetic patients and 15 controls, who had been angiographically determined to have normal coronary arteries. LV ejection fraction (LVEF) and the percentage change in LVEF during dobutamine infusion (DeltaLVEF) were measured as an index of LV function. In order to evaluate coronary flow reserve, coronary flow velocity was recorded using a Doppler guide wire. There were no significant differences in LVEF. DeltaLVEF was significantly lower in the diabetic patients than in the control subjects (p<0.01). Although there was no significant difference in the baseline coronary volumetric flow between the two groups, values during maximal hyperemia were significantly less in the diabetic patients than in the controls (p<0.05). Consequently, coronary flow reserve was significantly lower (p=0.0001). A significant positive correlation between coronary flow reserve and DeltaLVEF was exhibited (r=0.68, p=0.0009). Coronary flow reserve, an indicator of c...Continue Reading

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Citations

Jun 4, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S Vigili de Kreutzenberg, A Avogaro
Sep 26, 2013·Cardiovascular Diabetology·James T PearsonMikiyasu Shirai
Jan 21, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Lasse JespersenEva Prescott
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Oct 12, 2016·BMC Cardiovascular Disorders·Zhijun SunHongwei Li
May 21, 2017·The American Journal of Medicine·Son V Pham, Robert Chilton
Dec 9, 2016·Journal of the American Heart Association·Murat SezerBerrin Umman
Mar 19, 2019·Coronary Artery Disease·Adam J NelsonMatthew I Worthley

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