Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions

Atherosclerosis
Jacob L BarberMark A Sarzynski

Abstract

GlycA is a relatively new biomarker for inflammation as well as cardiometabolic disease risk. However, the effect of exercise on GlycA is largely unknown. Therefore, the purpose of this study was to examine the effects of regular exercise on the inflammatory marker GlycA across seven studies and 14 exercise interventions. Nuclear magnetic resonance spectroscopy, specifically signal amplitudes originating from the N-acetyl methyl group protons of the N-acetylglucosamine residues on the glycan branches of glycoproteins, was used to quantify GlycA concentrations. GlycA was measured before and after completion of an exercise intervention in 1568 individuals across seven studies and 14 exercise interventions. Random effects inverse variance weighting models were used to pool effects across interventions. Combined analysis of unadjusted data showed that regular exercise significantly (p = 2 × 10-6) reduced plasma GlycA (-8.26 ± 1.8 μmol/L). This reduction remained significant (-9.12 ± 1.9 μmol/L, p = 1.22 × 10-6) following adjustment for age, sex, race, baseline BMI, and baseline GlycA. Changes in GlycA were correlated with changes in traditional inflammatory markers, C-reactive protein, interleukin-6, and fibrinogen, however, these ...Continue Reading

Citations

Feb 6, 2020·Journal of Clinical Medicine·Rocío Fuertes-MartínNúria Amigó
Jan 11, 2020·Frontiers in Physiology·Marko TijardovićToma Keser
Feb 24, 2021·British Journal of Sports Medicine·Jacob L BarberMark A Sarzynski

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