Effects of remifentanil on the minimum alveolar concentration of isoflurane in dogs

American Journal of Veterinary Research
Eduardo R MonteiroLídia M Matsubara

Abstract

To evaluate the effects of remifentanil on isoflurane minimum alveolar concentration (ISO(MAC)) in dogs. 6 adult mixed-breed dogs. Dogs were anesthetized with isoflurane on 2 occasions. During the first set of experiments, ISO(MAC) was determined before remifentanil infusion (baseline), during constant rate infusion (CRI) of remifentanil (0.15, 0.30, 0.60, and 0.90 microg/kg/min), and 80 minutes after remifentanil infusion. After a 1-week washout period, dogs received a CRI of remifentanil (0.15 microg/kg/min) and ISO(MAC) was redetermined 2, 4, and 6 hours after commencing the infusion. Mean +/- SD baseline ISO(MAC) was 1.24 +/- 0.18%. Remifentanil infusion (0.15, 0.30, 0.60, and 0.90 microg/kg/min) decreased ISO(MAC) by 43 +/- 10%, 59 +/- 10%, 66 +/- 9%, and 71 +/- 9%, respectively. The ISO(MAC) values determined during the 0.30, 0.60, and 0.90 microg/kg/min infusion rates did not differ from each other, but these values were significantly lower, compared with the 0.15 microg/kg/min infusion rate. The ISO(MAC) recorded after remifentanil infusion (1.09 +/- 0.18%) did not differ from baseline ISO(MAC). There was no change in ISO(MAC) throughout the 6-hour period of a CRI of remifentanil. Remifentanil decreased ISO(MAC) in a do...Continue Reading

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Citations

Jun 2, 2011·Veterinary Anaesthesia and Analgesia·Tatiana H FerreiraAntonio J A Aguiar
Mar 29, 2014·Veterinary Anaesthesia and Analgesia·Perrine BenmansourTanya Duke-Novakovski
Apr 16, 2015·Journal of the American Veterinary Medical Association·Paulo V M SteagallPatrick M Burns
Mar 24, 2017·Anesthesia and Analgesia·Tatjana BevansChristopher Reilly
Apr 3, 2015·Journal of Feline Medicine and Surgery·Elisa Bortolami, Emma J Love
May 22, 2018·The Journal of Veterinary Medical Science·Yusuke MurahataTomohiro Imagawa
Feb 3, 2020·Veterinary Anaesthesia and Analgesia·Patricia Ruíz-LópezMaría Del Mar Granados

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