Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension

Journal of Diabetes Research
Ulla KampmannPer L Poulsen

Abstract

Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. Afferent signaling from the kidneys elevates the central sympathetic drive. We investigated the effect of catheter-based renal sympathetic denervation (RDN) on glucose metabolism, inflammatory markers, and blood pressure in nondiabetic patients with treatment-resistant hypertension. Eight subjects were included in an open-labelled study. Each patient was studied before and 6 months after RDN. Endogenous glucose production was assessed by a 3-3H glucose tracer, insulin sensitivity was examined by hyperinsulinemic euglycemic clamp, hormones and inflammatory markers were analyzed, and blood pressure was measured by office blood pressure readings and 24-hour ambulatory blood pressure monitoring. Insulin sensitivity (M-value) increased nonsignificantly from 2.68 ± 0.28 to 3.07 ± 0.41 (p = 0.12). A significant inverse correlation between the increase in M-value and BMI 6 months after RDN (p = 0.03) was found, suggesting beneficial effects on leaner subjects. Blood pressure decreased significantly, but there were no changes in hormones, inflammatory markers, or endogenous glucose production. Our results indicate that RDN may improve...Continue Reading

References

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Citations

Mar 8, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher T BanekJohn W Osborn
Nov 28, 2019·Current Hypertension Reports·Mariana Rodrigues Pioli, Ana Paula de Faria
Mar 19, 2019·Hypertension·Christopher T BanekJohn W Osborn

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Methods Mentioned

BETA
contraception
X-ray
dissection
sedation

Clinical Trials Mentioned

NCT01631370

Software Mentioned

Sigma Plot

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