Abstract
The effects of repeated treatment of rolipram, a cAMP specific phosphodiesterase inhibitor (0.1 mg/kg/day i.p., 14 days), on several neuronal cholinergic indices, especially on those in aged rats were examined. In young-adult rats, rolipram treatment increased choline acetyltransferase (ChAT) activity (V(max)value) in the striatum as well as in thalamus + midbrain, whereas it decreased choline esterase activity in the hippocampus. The ChAT activity (V(max)value) and the M1-R binding (B(max)value) in the aged control rats were significantly reduced in all the brain regions examined, compared with the young-adult rats, but consecutive rolipram treatment ameliorated the reductions of both indices in the frontal cortex and the hippocampus to approximately the young-adult control levels. Since high membrane binding site concentrations for rolipram itself were revealed in the frontal cortex and the hippocampus, where the rolipram treatment showed ameliorating effects on the ChAT activity and the M1-R binding, the present findings indicate that repeated rolipram administration easily affects these two brain regions. Thus, repeated rolipram administration could restore both the presynaptic ChAT activity and the postsynaptic muscarinic ...Continue Reading
References
Dec 25, 1976·Lancet·P Davies, A J Maloney
Jan 22, 1977·Lancet·E K PerryB E Tomlinson
Dec 29, 1978·Brain Research·T D ReisineS J Enna
Feb 1, 1975·Journal of Neurochemistry·F Fonnum
Apr 1, 1992·Journal of Neurochemistry·S BejaninJ Mallet
Apr 1, 1990·Trends in Pharmacological Sciences·J A Beavo, D H Reifsnyder
Jan 1, 1989·Journal of Neural Transmission·H Wachtel
Dec 4, 1989·Brain Research·P KaulenH G Baumgarten
Aug 7, 1986·European Journal of Pharmacology·H H SchneiderJ Seidler
Jul 1, 1988·International Clinical Psychopharmacology·A BertolinoM Schratzer
Oct 1, 1988·Neurochemical Research·K HabaA Mori
Jan 1, 1985·Journal of Neural Transmission·W KehrR Neumeister
Jan 1, 1982·Psychopharmacology·H Wachtel
May 15, 1984·Biochemical Pharmacology·H H Schneider
Mar 1, 1983·Neuropharmacology·H Wachtel
Feb 14, 1984·Biochemical and Biophysical Research Communications·W R Roeske, J C Venter
Aug 1, 1981·Annals of Neurology·P J WhitehouseM R DeLong
Mar 1, 1959·Clinica Chimica Acta; International Journal of Clinical Chemistry·F RAPPAPORTN PINTO
Citations
Sep 5, 1996·Brain Research. Molecular Brain Research·M AsanumaN Ogawa
Dec 6, 1997·European Journal of Pharmacology·N YamashitaA Sawa
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·J S SilvestreJ M Palacios
Dec 6, 2005·Alzheimer Disease and Associated Disorders·Yvette AkwaMartine Vercelletto
Jul 23, 2014·PloS One·Jane S SutcliffeIgnacio Munoz-Sanjuan
Jun 21, 2008·Journal of Neurochemistry·Mark S YeomanDanny O'Hare
Jun 8, 2012·Alcoholism, Clinical and Experimental Research·Rui-Ting WenJian-Hui Liang
Dec 15, 2012·Neuroscience·D J TitusC M Atkins
Jul 29, 1998·Japanese Journal of Pharmacology·F OhsawaA Sawa
Oct 27, 2015·Journal of Molecular Modeling·Naga Srinivas Tripuraneni, Mohammed Afzal Azam
May 21, 2010·Journal of Pharmacological Sciences·Hideo FukuiHatsue Furukawa