PMID: 15374348Mar 1, 1993Paper

Effects of repeated administration of rolipram, a cAMP-specific phosphodiesterase inhibitor, on acetylcholinergic indices in the aged rat brain

Archives of Gerontology and Geriatrics
M AsanumaA Mori

Abstract

The effects of repeated treatment of rolipram, a cAMP specific phosphodiesterase inhibitor (0.1 mg/kg/day i.p., 14 days), on several neuronal cholinergic indices, especially on those in aged rats were examined. In young-adult rats, rolipram treatment increased choline acetyltransferase (ChAT) activity (V(max)value) in the striatum as well as in thalamus + midbrain, whereas it decreased choline esterase activity in the hippocampus. The ChAT activity (V(max)value) and the M1-R binding (B(max)value) in the aged control rats were significantly reduced in all the brain regions examined, compared with the young-adult rats, but consecutive rolipram treatment ameliorated the reductions of both indices in the frontal cortex and the hippocampus to approximately the young-adult control levels. Since high membrane binding site concentrations for rolipram itself were revealed in the frontal cortex and the hippocampus, where the rolipram treatment showed ameliorating effects on the ChAT activity and the M1-R binding, the present findings indicate that repeated rolipram administration easily affects these two brain regions. Thus, repeated rolipram administration could restore both the presynaptic ChAT activity and the postsynaptic muscarinic ...Continue Reading

References

Dec 29, 1978·Brain Research·T D ReisineS J Enna
Apr 1, 1990·Trends in Pharmacological Sciences·J A Beavo, D H Reifsnyder
Aug 7, 1986·European Journal of Pharmacology·H H SchneiderJ Seidler
Jan 1, 1985·Journal of Neural Transmission·W KehrR Neumeister
Mar 1, 1959·Clinica Chimica Acta; International Journal of Clinical Chemistry·F RAPPAPORTN PINTO

❮ Previous
Next ❯

Citations

Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·J S SilvestreJ M Palacios
Dec 6, 2005·Alzheimer Disease and Associated Disorders·Yvette AkwaMartine Vercelletto
Jul 29, 1998·Japanese Journal of Pharmacology·F OhsawaA Sawa
May 21, 2010·Journal of Pharmacological Sciences·Hideo FukuiHatsue Furukawa

❮ Previous
Next ❯

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.