Effects of repeated exposures of hydrogen sulphide on rat hippocampal EEG

Toxicology Letters
B SkrajnyS H Roth

Abstract

Exposure to high levels of hydrogen sulphide (H2S) in humans has been associated with a number of respiratory and neurological symptoms. Acute toxicity following exposure to high concentrations is well-documented, however, there is little scientific information concerning the effects of exposure to low concentrations. The effects of low levels of H2S on electroencephalographic (EEG) activity in the hippocampus and neocortex were investigated on the freely moving rat (Sprague-Dawley). Hippocampal electrodes were implanted in the dentate gyrus (DG) and CA1 region. Activity was recorded for 10 min just prior to H2S exposure in the presence of air (pre-exposure). Rats were exposed to H2S (25, 50, 75, or 100 ppm) for 3 h/day; data was collected during the final 10 min of each exposure. The total power of hippocampal theta activity increased in a concentration-dependent manner in both DG and CA1; repeated exposures for 5 consecutive days resulted in a cumulative effect that required 2 weeks for complete recovery. The effects were found to be highly significant at all concentrations within subjects. Neocortical EEG and LIA (Large Amplitude Irregular Activity) were unaffected. The results demonstrate that repeated exposure to low level...Continue Reading

References

Nov 1, 1992·Canadian Journal of Physiology and Pharmacology·B SkrajnyS H Roth
Jan 1, 1992·Annual Review of Pharmacology and Toxicology·R J ReiffensteinS H Roth
Jan 1, 1991·American Journal of Industrial Medicine·B TvedtT Mathiesen
May 1, 1990·Toxicology and Industrial Health·L J HaydenS H Roth
May 8, 1989·Neuroscience Letters·R S HannahS H Roth
Aug 1, 1989·Archives of Neurology·H H WaschJ E Cone
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1987·Physiology & Behavior·R S SainsburyC P Montoya
Jan 1, 1984·Critical Reviews in Toxicology·R O BeauchampD A Andjelkovich
Aug 1, 1993·Progress in Neurobiology·B H Bland, L V Colom
Jan 1, 1993·Brain Research Bulletin·R S Sainsbury, L A Partlo
Jan 1, 1993·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·F M CorriganN I Ward

❮ Previous
Next ❯

Citations

Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Toshihiko Ubuka
Mar 28, 2003·Occupational and Environmental Medicine·Michael G Costigan
May 28, 2010·Toxicology and Industrial Health·Kaye H KilburnMichael R Gray
Nov 16, 2010·International Journal of Toxicology·Tee L Guidotti
Oct 16, 2009·Inhalation Toxicology·Thomas MarshallFemi Adeshina
Aug 9, 2020·International Journal of General Medicine·Johann Lechner, Wolfgang Mayer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.