Effects of repeated maprotiline and fluoxetine treatment on gene expression of catecholamine synthesizing enzymes in adrenal medulla of unstressed and stressed rats

Autonomic & Autacoid Pharmacology
N SpasojevicS Dronjak

Abstract

1 Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of catecholamine biosynthetic enzymes were examined in adrenal medulla of unstressed control and chronic unpredictable mild stressed rats. 2 Maprotiline did not change gene expression of catecholamine biosynthetic enzymes in control and stressed rats. 3 Fluoxetine increased gene expression of tyrosine hydroxylase (TH) and dopamine-β-hydroxylase (DBH), but did not phenylethanolamine N-methyltransferase in both unstressed and chronic unpredictable mild stressed animals. 4 In conclusion, we have demonstrated that repeated administration of fluoxetine enhanced gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in adrenal medulla of control and stressed rats.

References

Jul 1, 1992·Neuropharmacology·C Moret, M Briley
Nov 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D L WongJ W Funder
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·P WillnerM Papp
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E J NestlerR S Duman
Apr 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S A Montgomery
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Angela J GrippoAlan Kim Johnson
May 22, 2002·Molecular Pharmacology·T C TaiDona L Wong
Mar 3, 2005·Neuropsychobiology·Patrizia BlardiPaolo Castrogiovanni
Jan 11, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Koji ShinkaiNobuyuki Yanagihara
Dec 17, 2008·Autonomic Neuroscience : Basic & Clinical·Natasa SpasojevicSladjana Dronjak
Apr 4, 2009·Physiological Reviews·Richard KvetnanskyMiklos Palkovits
Jun 2, 2009·Autonomic Neuroscience : Basic & Clinical·Ljubica GavrilovicSladjana Dronjak
Sep 11, 2009·Autonomic & Autacoid Pharmacology·P J Fitzgerald

❮ Previous
Next ❯

Citations

Oct 24, 2012·Journal of Natural Medicines·Bombi LeeDae-Hyun Hahm
Jul 19, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Magda M SantanaCláudia Cavadas
Jul 4, 2015·BMC Complementary and Alternative Medicine·Bombi LeeDae-Hyun Hahm
Jul 1, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Bombi LeeDae-Hyun Hahm
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Bombi LeeDae-Hyun Hahm
May 23, 2020·Metabolic Brain Disease·Lu TianPeng Xie
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Swati Sahoo, Brijesh S
Jul 24, 2021·Journal of Pharmacological Sciences·José Ángel García-PedrazaMónica García-Domingo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.