Effects of repeated ozone exposure on pulmonary function and bronchial responsiveness in mice sensitized with ovalbumin

Toxicology
Hidemitsu FunabashiTakayuki Kuriyama

Abstract

We examined the effect of repeated ozone exposure on the respiratory system in mice, sensitized with ovalbumin (OA). OA-sensitized mice and saline-treated control mice were exposed to 1.0 ppm ozone or clean air for 6 h daily and five days weekly for five weeks. Subsequently, these mice were exposed to 1.0 ppm ozone for 1 h, and pulmonary function was evaluated by pneumotachography during ozone exposure and arterial blood gas analysis and histopathological examination were performed. OA sensitization or repeated ozone exposure did not affect baseline pulmonary function. In OA-sensitized mice receiving repeated ozone exposure, acute ozone exposure increased respiratory resistance and decreased dynamic compliance, with significant differences in both parameters compared with, after repeated ozone exposure without OA sensitization. In mice without repeated exposure, there was no difference in the effect of acute ozone exposure according to the use of OA sensitization. After 1-h exposure, arterial blood gas analysis showed a significant decrease in PaO2 in mice undergoing OA sensitization alone, with no significant reduction of this parameter in mice receiving repeated exposure. Histopathologically, alveolar epithelial hyperplasia o...Continue Reading

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Citations

Apr 28, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gin C ChuangScott W Ballinger
Mar 7, 2014·PloS One·Madeleine Chalfant, Karen K Bernd
Nov 28, 2013·Journal of Toxicology and Environmental Health. Part a·Jitka Stilund HansenSøren Thor Larsen
Sep 29, 2011·Molecular and Cellular Biochemistry·Rama Surya Prakash PerepuRajat Sethi
Jan 23, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Na SunHaidong Kan

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