Effects of repeated restraint stress on hypothalamo-pituitary-adrenocortical function in vasopressin deficient Brattleboro rats

Brain Research Bulletin
D ZelenaG B Makara

Abstract

Arginine-vasopressin (AVP) has been proposed to be an important mediator during chronic stress in the regulation of the hypothalamo-pituitary-adrenal axis. In the present study we addressed the role of AVP in maintaining adrenocortical responsiveness during chronic stress using the AVP deficient mutant Brattleboro rat. Heterozygous Brattleboro rats (di/+) served as controls and were compared to homozygous rats (di/di) with diabetes insipidus. Sixty minutes daily restraint was repeated for 5, 8, 11 or 15 days and organ weights, plasma adrenocorticotropin (ACTH) and corticosterone levels and anterior pituitary proopiomelanocortin (POMC) mRNA and ACTH content were measured. The body, adrenal and thymus weight changes induced by chronic stress became significant between 5 and 8 repetition and AVP deficiency had no effect on these parameters. The first indication that AVP has a role to play appears after 11 repetitions. In the di/di group at the end of 11th restraint, the plasma ACTH was decreased when compared to the di/+ rats. In animals with indwelling cannulas some adaptation could be seen in ACTH response without any difference between di/+ and di/di rats after 15 restraints. The corticosterone- and prolactin-elevations induced...Continue Reading

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Citations

Apr 25, 2012·Cellular and Molecular Neurobiology·Gábor B MakaraDóra Zelena
Jun 19, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Igor I KhegayLudmila N Ivanova
Jul 11, 2006·Endocrine Journal·Kyuzi KamoiMasashi Miyakoshi
Jul 26, 2006·Inhalation Toxicology·S van EijlN Bloksma
May 22, 2007·Stress : the International Journal on the Biology of Stress·Greti AguileraAnna Kamitakahara
Jan 27, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·H Bobby Fokidis, Pierre Deviche
Jul 21, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melinda G ArnettLouis J Muglia
Jun 23, 2007·Annals of the New York Academy of Sciences·Kunio YuiiMasayoshi Kurachi
Feb 16, 2008·European Journal of Pharmacology·Elisabeth Frank, Rainer Landgraf
Sep 11, 2010·Stress : the International Journal on the Biology of Stress·Ja RoperSj Lolait
Jan 6, 2009·Annals of the New York Academy of Sciences·Jun ChenGreti Aguilera
Sep 8, 2005·American Journal of Physiology. Endocrinology and Metabolism·Dóra ZelenaGábor B Makara
Oct 18, 2012·Physiological Reviews·Taka-aki KoshimizuAkito Tanoue
May 17, 2019·British Journal of Pharmacology·Nikolaos KokrasChristina Dalla
Dec 9, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dóra ZelenaGábor B Makara
Apr 7, 2007·Endocrinology·Sivan Subburaju, Greti Aguilera
Oct 20, 2007·Molecular and Cellular Endocrinology·Esther A GuzmánLaurie B Owen

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