PMID: 2508157Jan 1, 1989Paper

Effects of repeated ritanserin on middle-aged poor sleepers

Psychopharmacology
K Adam, I Oswald

Abstract

Nine subjects who believed themselves to be poor sleepers, of mean age 58 years, took a placebo for 7 days, then ritanserin 5 mg for 20 days, followed by 3 days on placebo. Sleep was recorded electrophysiologically on 2 nights during baseline, 2 early drug nights, 2 late drug nights and the 2nd and 3rd withdrawal nights. Ratings of sleep quality were collected each morning. Ritanserin, a 5HT2 antagonist, caused a persistent doubling of the amount of EEG slow wave sleep, without altering the total duration of sleep. Ritanserin decreased the frequencies of awakening and after about a week it appeared to improve the subjective quality of sleep. Sleep was then impaired during withdrawal, as indicated by decreased duration and poorer subjective quality, being worst on the 3rd withdrawal night.

References

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Citations

Jan 1, 1991·European Archives of Psychiatry and Clinical Neuroscience·A A BorbélyI Oswald
Jan 15, 1995·Biological Psychiatry·A L Sharpley, P J Cowen
Jan 1, 1994·Journal of Psychosomatic Research·C Idzikowski
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·R H PastelF C Tortella
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·A M CoenenE L van Luijtelaar
Nov 1, 1996·Drug and Alcohol Dependence·R N EhrmanC P O'Brien
Mar 23, 2004·Sleep Medicine Reviews·Jaime M Monti, Daniel Monti
Mar 19, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antoine U ViolaRemy Luthringer
Feb 1, 1991·British Journal of Clinical Pharmacology·C IdzikowskiR J James
Oct 4, 2011·Sleep·Akifumi KishiYoshiharu Yamamoto
Sep 1, 1996·Journal of Endocrinological Investigation·G BrandenbergerM Follenius
Apr 5, 2011·Sleep Medicine Reviews·Jaime M Monti
Feb 24, 2011·Sleep Medicine Clinics·Timothy Roehrs, Thomas Roth
Apr 19, 2011·Sleep Medicine Clinics·Andrew D Krystal
Oct 24, 2020·Scientific Reports·Christopher J Davis, William M Vanderheyden

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