Effects of repeated short-term skin contact with proteolytic enzymes

Contact Dermatitis
Min Young LeeR Dana Laurie

Abstract

The objective was to investigate effects on the hand of protease used in dishwashing liquids (DWL). A group of 30 Koreans (normal skin) and 24 Japanese (12 atopic and 12 normal) were employed for two different studies, respectively. The 30 Koreans were divided into three groups. Each group immersed their hands for 15 min a day for 9 days into DWL containing 0.005% protease, 0.02% protease, or non-enzyme DWL. The 24 Japanese immersed their hands for 15 min a day for 4 days into 0.005% protease-containing or a non-enzyme DWL. The hand skin was evaluated by measuring overall and dry skin grades, estimated before and after exposures to the test products. The Korean study shows that 0.005% and 0.02% protease-containing DWL are less irritating to the skin than non-enzyme control, as measured by better overall skin grades and less dry skin. The Japanese study shows that 0.005% protease-containing DWL are less irritating to the skin than non-enzyme control in both atopic and normal subjects. The 0.005% protease use did not cause any adverse dermatological effects to atopic subjects compared with non-enzyme control. Both studies indicate that 0.005% and 0.02% protease resulted in better skin mildness profile, without causing adverse der...Continue Reading

References

Sep 1, 1985·Contact Dermatitis·I R WhiteA el Alami
Mar 23, 1970·JAMA : the Journal of the American Medical Association·R O Carter, K D McMurrain
May 29, 1971·British Medical Journal·R M BolamL T Bowerman
Mar 1, 1995·Contact Dermatitis·A Hannuksela, M Hannuksela
Mar 1, 1994·Contact Dermatitis·P H AndersenH I Maibach

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Citations

Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Seok KwonPetra Kern
May 23, 2008·International Journal of Cosmetic Science·A V Rawlings

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