PMID: 3091427Sep 1, 1986Paper

Effects of repeated stimuli on prolactin release in vitro from normal and adenomatous rat lactotrophs

Molecular and Cellular Endocrinology
J Lafond, R Collu


It is now well known that dopamine (DA) plays a major role in the inhibitory control of prolactin (PRL); however, the mechanisms that are physiologically involved in the stimulation of PRL release are still under investigation. Indeed, although suppression of DA inhibitory tonus, administration of thyrotropin-releasing hormone (TRH) or vasoactive intestinal peptide (VIP) are all known PRL releasers, it is not clear whether they interact during physiological periods of PRL release such as suckling and estrus. No clear indications exist, furthermore, on whether they all act upon a same pituitary pool that may become depleted following repeated exposure to stimuli. Refractoriness to a single or a repeated stimulus has been reported to occur in prolactinoma-bearing or normal humans, respectively, the mechanism of which is still matter for discussion. Our present studies performed by perifusing normal or adenomatous rat lactotrophs attached to Cytodex I microcarrier beads was undertaken to try and answer some of these questions. The experimental period consisted in perifusing the cells for 1 h with Dulbecco's modified Eagle's medium (DMEM) containing DA 10(-5) M, then for 2 h with either DMEM, DMEM and TRH 10(-8) M, DMEM and VIP 10(...Continue Reading


Mar 17, 1977·The New England Journal of Medicine·D L KleinbergA G Frantz
May 23, 1974·The New England Journal of Medicine·K M GautvikJ E Zuckerman
Sep 1, 1984·Acta Endocrinologica·A I TorresA Aoki

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