PMID: 11330336May 2, 2001Paper

Effects of repeated systemic administration of d-Fenfluramine on serotonin and glutamate release in rat ventral hippocampus: comparison with methamphetamine using in vivo microdialysis

Naunyn-Schmiedeberg's Archives of Pharmacology
C Rocher, A M Gardier

Abstract

We compared the effects of three systemic injections of various doses of d-Fenfluramine, an indirect serotonergic agonist (1.3, 5 or 10 mg/kg), to those of a known neurotoxin, methamphetamine (METH, at a 7.5 mg/kg dose), given i.p. at 2-h intervals, simultaneously on extracellular levels of glutamate [Gluext] and 5-HT [5-HText] in the ventral hippocampus (VHPC) using in vivo microdialysis in conscious rats. METH markedly increased both [Gluext] (+77% over the control value in saline-treated rats) and [5-HText] (around +250% over controls) in the VHPC. d-Fenfluramine, at all the doses studied, induced gradual increases of [5-HText] in the VHPC (between +125% and +417% over control values), but did not modify [Gluext]. These data highlight marked in vivo differences between METH and d-Fenfluramine in their effects on extracellular levels of 5-HT and Glu in the rat ventral hippocampus following their repeated systemic administration.

Citations

Jan 11, 2005·Neurotoxicity Research·H G Baumgarten, L Lachenmayer
May 15, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Romana SlamberováRichard Rokyta
Aug 19, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Bryan K Yamamoto, Jamie Raudensky
Sep 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Justin T GassM Foster Olive
Jun 27, 2006·The AAPS Journal·Maria S Quinton, Bryan K Yamamoto
Nov 29, 2014·Molecular Neurobiology·Waldo CerpaNibaldo C Inestrosa
Feb 24, 2007·Progress in Neurobiology·Christian P MüllerMaria A De Souza Silva
Nov 11, 2008·Annals of the New York Academy of Sciences·Frederico C PereiraTice R Macedo
Mar 6, 2010·Annals of the New York Academy of Sciences·Bryan K YamamotoGary A Gudelsky
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Jan 21, 2014·Neuropharmacology·Joana GonçalvesAna Paula Silva
Jan 3, 2007·Brain Research·Jamie Raudensky, Bryan K Yamamoto
Jun 23, 2010·Drug and Alcohol Dependence·Yong An ChungDai Jin Kim
Jun 21, 2017·The Journal of Pharmacology and Experimental Therapeutics·Anna Moszczynska, Sean Patrick Callan
Feb 7, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yaroslav I MolkovDmitry V Zaretsky
May 12, 2006·The Journal of Pharmacology and Experimental Therapeutics·Kristi S RauAnnette E Fleckenstein
Nov 27, 2016·Journal of Molecular Neuroscience : MN·Fahad S AlshehriYoussef Sari

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