Effects of resective surgery for left-sided intracranial tumours on language function: a prospective study

Lancet
I R WhittleR Taylor

Abstract

Although language disorders occur in about 50% of patients with a left hemispheric tumour and are a significant cause of morbidity, the effects of resective neurosurgery and their relation to tumour pathology are unclear. We report the immediate effects of resective surgery on language functions in a heterogeneous group of patients with left-sided intracranial tumours. 40 patients were studied. The Western Aphasia Battery (WAB) and Boston Naming Test (BNT) were administered preoperatively and before discharge following resective neurosurgery. Dexamethasone dose at time of testing was recorded, as was time taken to complete the tests, and tumour neuropathology. 15 patients with normal aphasia quotients and language quotients before resective surgery all had normal quotients postoperatively. 25 who were dysphasic (ie, aphasia quotient <93.8) preoperatively showed significant postoperative improvements in both their mean aphasia quotient (from 81.8 to 89.1, p=0.004) and their mean language quotient (from 73.4 to 85.4, p=0.001), though 13 remained dysphasic. Two of the 25 dysphasic patients had their WAB scores lowered by tumour resection. The findings and postoperative changes in BNT scores were almost identical to the pattern of ...Continue Reading

References

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Citations

Jun 21, 2005·Lancet Neurology·Patrick MitchellA David Mendelow
Nov 7, 2001·Acta Neurologica Scandinavica·J GbadamosiC Heesen
Nov 15, 2015·Acta neurochirurgica·Djaina SatoerArnaud Vincent
May 12, 2004·Lancet·Ian R WhittleDonald Collie
Jun 27, 2015·Journal of Neurosurgery·Stephen M WilsonEdward F Chang
Nov 1, 2001·The Cochrane Database of Systematic Reviews·S E Metcalfe, R Grant
Sep 23, 2006·Acta neurochirurgica·K SakuradaT Kayama
Jun 7, 2019·The Cochrane Database of Systematic Reviews·Michael G HartRobin Grant
Oct 24, 2017·Aphasiology·Angelica McCarronStephen M Wilson
May 5, 2000·The Cochrane Database of Systematic Reviews·S E Metcalfe
Apr 1, 2021·Neuropsychology Review·Christos PapatzalasIlias Papathanasiou

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