PMID: 1202364Nov 21, 1975Paper

Effects of reserpine and propranolol on anoxia-induced enzyme release from the isolated perfused guinea-pig-heart

Naunyn-Schmiedeberg's Archives of Pharmacology
K Sakai, P G Spieckermann

Abstract

The possibility of a protective effect by reserpine or propranolol on anoxia-induced released of malate and lactate dehydrogenase was investigated in isolated perfused hearts of guinea-pigs. After allowing 30 min of aerobic perfusion for the development of a steady state, the hearts from the nontreated group as well as the reserpine-pretreated or propranolol-treated group were subjected to a prolonged anoxia of 5 hrs. A marked enzyme release which occurred from the anoxic nontreated hearts was significantly inhibited by reserpine or propranolol. These findings suggest that the enzyme release from the anoxic myocardium is partly related to the liberation of endogenous catecholamines.

References

Nov 1, 1975·Journal of Molecular and Cellular Cardiology·K SakaiH J Bretschneider
Mar 1, 1970·European Journal of Pharmacology·J Wagner
Aug 1, 1973·Journal of Molecular and Cellular Cardiology·D J HearseE B Chain
Jun 14, 1974·Nature·J H Wilkinson, J M Robinson
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Oct 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE
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Citations

Oct 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·W Bernauer
Sep 11, 1987·European Journal of Pharmacology·M InoueM Fujiwara
Jun 1, 1985·Journal of the American College of Cardiology·W KüblerJ Senges
Mar 1, 1979·British Journal of Pharmacology·E Welman
Aug 19, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·O KaracaliogluM Ozguven
Aug 1, 1978·The American Journal of Cardiology·W G NaylerR Ferrari
Sep 1, 1993·Perception & Psychophysics·R G ErensJ J Koenderink
May 1, 1986·Basic Research in Cardiology·A Beresewicz, E Karwatowska-Kryńska

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