Effects of resistance exercise intensity on extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase activation in men

Journal of Strength and Conditioning Research
Lem TaylorDarryn S Willoughby

Abstract

Extracellular signal-regulated kinase (ERK) 1/2 signaling has been shown to be increased after heavy resistance exercise and suggested to play a role in the hypertrophic adaptations that are known to occur with training. However, the role that ERK1/2 may play in response to lower intensities of resistance exercise is unknown. Therefore, the purpose of this study was to determine the effects of resistance exercise intensity on ERK1/2 activity in human skeletal muscle. Twelve recreationally active men completed separate bouts of single-legged resistance exercise with 8-10 repetitions (reps) at 80-85% 1 repetition maximum (1RM) (85%) and 18-20 reps at 60-65% 1RM (65%) in a randomized crossover fashion. For both resistance exercise sessions, vastus lateralis biopsies and blood draws were taken immediately before exercise (PRE) and at 30 minutes (30MPST), 2 hours (2HRPST), and 6 hours (6HRPST) post exercise, with an additional blood draw occurring immediately after exercise (POST). The phosphorylated levels of pIGF-1R, pMEK1, pERK1/2, and activated Elk-1 were assessed by phosphoELISA, and serum insulin-like growth factor 1 (IGF-1) was assessed via enzyme-linked immunosorbent assay. Statistical analyses used a 2 × 4 (muscle responses...Continue Reading

References

Oct 1, 1990·Journal of Applied Physiology·W J KraemerS J Fleck
Sep 1, 1985·The Journal of Physiology·P Andersen, B Saltin
Oct 1, 1995·Journal of Applied Physiology·W J KraemerK Häkkinen
Mar 7, 1997·The Journal of Biological Chemistry·S A CoolicanJ R Florini
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·U WidegrenJ R Zierath
Jan 23, 1999·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·G E McCallW J Kraemer
Sep 14, 1999·Journal of Applied Physiology·W J KraemerW J Evans
Feb 24, 2001·Pflügers Archiv : European journal of physiology·U WidegrenJ Henriksson
Mar 15, 2001·Journal of Applied Physiology·B C NindlG A Loomis
Apr 12, 2001·Journal of Applied Physiology·G A Nader, K A Esser
Jun 19, 2002·Journal of Applied Physiology·Fadia Haddad, Gregory R Adams
Aug 8, 2002·Medicine and Science in Sports and Exercise·Darryn S Willoughby, Matthew J Nelson
Aug 17, 2002·Journal of Applied Physiology·Gregory R Adams
Aug 21, 2003·Trends in Molecular Medicine·David J Glass
Dec 4, 2003·Medicine and Science in Sports and Exercise·Darryn S WilloughbyLemuel Taylor
Jan 30, 2004·Exercise and Sport Sciences Reviews·John A Hawley, Juleen R Zierath
Mar 5, 2004·American Journal of Physiology. Endocrinology and Metabolism·Håkan K R KarlssonEva Blomstrand
Mar 23, 2004·Journal of Applied Physiology·Jascha D ParkingtonRoger A Fielding
Sep 10, 2005·European Journal of Applied Physiology·Carsten LundbyHenriette Pilegaard
Dec 24, 2005·Journal of Applied Physiology·Fadia Haddad, Gregory R Adams
Feb 26, 2008·Journal of Strength and Conditioning Research·Blair CrewtherChristian Cook
Jan 9, 2009·Journal of Strength and Conditioning Research·Jeffrey M McBrideN Travis Triplett
Feb 11, 2009·Medicine and Science in Sports and Exercise·UNKNOWN American College of Sports Medicine
Oct 15, 2009·Journal of Strength and Conditioning Research·Colin D WilbornDarryn S Willoughby

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Citations

Jun 24, 2016·European Journal of Applied Physiology·Adam M GonzalezJeffrey R Stout
Nov 9, 2017·Journal of Exercise Rehabilitation·Víctor L Escamilla-GalindoManuel Sillero-Quintana
Dec 29, 2017·Journal of Strength and Conditioning Research·Rebecca A KudrnaMichael R Prewitt
Apr 8, 2020·Journal of Physical Activity & Health·Diego de Alcantara BorbaMarco Túlio de Mello
May 16, 2019·Physiological Reports·Evgeny A LysenkoOlga L Vinogradova
Jun 23, 2019·International Journal of Molecular Sciences·Sergio Di MeoPaola Venditti
Dec 18, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·James L DevinTina L Skinner

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