PMID: 11915909Mar 28, 2002Paper

Effects of resistance training on the rate of muscle protein synthesis in frail elderly people

International Journal of Sport Nutrition and Exercise Metabolism
J N Schulte, K E Yarasheski

Abstract

Advancing age is associated with a reduction in skeletal muscle protein, muscle strength, muscle quality, and chemical modifications that may impair protein function. Sarcopenia has been coupled with physical disability, frailty, and a loss of independent function. Using stable isotope tracer methodologies and mass spectrometric detection, we observed: (a) 76-92-year-old physically frail and 62-74-year-old middle-age adults have lower mixed muscle protein synthetic rates than 20-32-year-old men and women; (b) 2 weeks and 3 months of weightlifting exercise increased the synthetic rate of myosin heavy chain (MHC) and mixed muscle proteins to a similar magnitude in frail, middle-age, and young women and men; (c) Serum myostatin-immunoreactive protein levels were elevated in physically frail women and were inversely correlated with lean mass. This suggests that the protein synthetic machinery adapts rapidly to increased contractile activity and that the adaptive response(s) are maintained even in frail elders.

Citations

Jun 26, 2003·American Journal of Physiology. Endocrinology and Metabolism·Suzanne Reisz-PorszaszNestor F Gonzalez-Cadavid
Jun 12, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Nestor F Gonzalez-Cadavid, Shalender Bhasin
May 6, 2004·Medicine and Science in Sports and Exercise·Kylie S WalkerHeather K Smith
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jeong-su KimMarcas M Bamman
Apr 25, 2012·Endocrine·Scott C ForbesDarren G Candow
Dec 6, 2014·International Journal of Evidence-based Healthcare·Solomon YuRenuka Visvanathan
Aug 26, 2015·IUBMB Life·Mridula SharmaShruti Srinivasan
Apr 23, 2017·Cold Spring Harbor Perspectives in Medicine·Giovanna Distefano, Bret H Goodpaster
Oct 21, 2005·Journal of Geriatric Physical Therapy·Jack M CarterMichael S Witten
May 11, 2007·Scandinavian Journal of Medicine & Science in Sports·A I Kryger, J L Andersen
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Se-Jin Lee
Jul 5, 2007·American Journal of Physiology. Endocrinology and Metabolism·Anne Marie Winther PetersenBettina Mittendorfer
Nov 11, 2008·Journal of Endocrinological Investigation·I CarneiroV M Arce
Aug 31, 2006·Pflügers Archiv : European journal of physiology·Akihiko YamaguchiToshihiro Hirai
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Darren G Candow, Philip D Chilibeck
Dec 24, 2005·Journal of Applied Physiology·Fadia Haddad, Gregory R Adams
Jun 11, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Craig McFarlaneRavi Kambadur
Feb 22, 2012·Acta Physiologica·B ElliottR Mackenzie
May 18, 2011·Journal of Aging Research·Olga TheouGareth R Jones
Sep 28, 2018·Biogerontology·Rachel McCormick, Aphrodite Vasilaki
Aug 7, 2009·The Journal of Nutrition, Health & Aging·Y Boirie
Jun 12, 2012·Journal of Physiology and Biochemistry·Isabel CarneiroVíctor M Arce
Mar 10, 2004·AIDS Patient Care and STDs·Wesley D DudgeonGregory A Hand
Dec 13, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S CarterMarco Pahor
Oct 23, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marybeth BrownRob Gabriel
Nov 22, 2011·Journal of Nutrition in Gerontology and Geriatrics·Roschelle A Heuberger
Oct 31, 2012·European Journal of Applied Physiology·Catherine M JankowskiWendy M Kohrt
Jul 5, 2005·Journal of Aging and Physical Activity·Maureen Lucas, Cynthia J Heiss
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Takayuki MiuraTakanori Nishimura
Sep 5, 2018·Physiological Reports·Lady V Barrios-SilvaBradley T Elliott
Feb 7, 2021·BMC Musculoskeletal Disorders·Katharina Kerschan-SchindlPeter Pietschmann
Mar 27, 2007·Journal of the American Society for Mass Spectrometry·Randall J BatemanKevin E Yarasheski

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