Effects of resistant starch- and vitamin A-supplemented diets on the promotion of precursor lesions of colon cancer in rats

Nutrition and Cancer
P CassandJ F Narbonne

Abstract

We have evaluated the potential protective effect of resistant starch (RS)- and vitamin A-supplemented diets on the promotion of preneoplasic lesions of rat colon, aberrant crypt foci (ACF), induced by 1,2-dimethylhydrazine dihydrochloride (DMH). We have tried to show whether the association of these two dietary constituents in the same diet could have synergistic effects. RS, vitamin A, and RS+ vitamin A were incorporated into the rat diets. Experimental diets were given one week after DMH injection and maintained for 12 weeks until the animals were sacrificed. The total number of ACF decreased with the three experimental diets. For RS- and RS + vitamin A-supplemented diets, this decrease is primarily due to a decrease in small ACF. For the vitamin A-supplemented diet, small and large ACF have a tendency to decrease. The effects of the diets on parameters influencing colon carcinogenesis were also studied. Only RS- and RS + vitamin A-supplemented diets have modified cecal pH, fecal and cecal butyrate contents, fecal excretion, cecal weight, and colon length. Vitamin A has been observed in colonic epithelial cells of rats receiving vitamin A- and RS+ vitamin A-supplemented diets. The association between RS and vitamin A shows n...Continue Reading

References

Jan 1, 1990·Nutrition and Cancer·H L Newmark, J R Lupton
Jan 1, 1990·Nutrition and Cancer·G A KuneL F Watson
Jul 1, 1989·The British Journal of Nutrition·C AndrieuxE Sacquet
Apr 1, 1986·Journal of the National Cancer Institute·J D Potter, A J McMichael
Mar 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·B PeriquetJ P Thouvenot
Jul 1, 1971·Cancer·D P Burkitt
Jan 1, 1971·The American Surgeon·B P Colcock
May 16, 1981·Lancet·J R Thornton
Jul 1, 1995·The American Journal of Clinical Nutrition·J PhillipsG P Young
Nov 1, 1993·Mutation Research·P J Harris, L R Ferguson
Feb 8, 1995·International Journal of Cancer. Journal International Du Cancer·M J WargovichM Velasco
Sep 15, 1994·Biochimica Et Biophysica Acta·B A van Kuiken, W D Behnke
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·I P Van Munster, F M Nagengast
Jan 1, 1995·Nutrition and Cancer·H AbdelaliJ F Narbonne

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Citations

Feb 19, 2000·Journal of Cellular Biochemistry·C Avivi-GreenB Schwartz
Aug 10, 2001·Diseases of the Colon and Rectum·S SenguptaP R Gibson
Jul 3, 1998·Critical Reviews in Oncology/hematology·M A MooreH Tsuda
Jul 23, 1999·Mutation Research·P J Harris, L R Ferguson
Jun 30, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Abdiryim YusupPierrette Cassand
Feb 8, 2006·Journal of Gastroenterology and Hepatology·Shomik SenguptaPeter R Gibson
Jun 24, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ruiping Liu, Guifa Xu
Feb 24, 2015·The Proceedings of the Nutrition Society·Fiona C MalcomsonJohn C Mathers
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J H Cummings

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