PMID: 2507508Sep 1, 1989Paper

Effects of respiratory drive on upper airways in sleep apnea patients and normal subjects

Journal of Applied Physiology
F SérièsJ La Forge

Abstract

We compared the changes in nasal and pharyngeal resistance induced by modifications in the central respiratory drive in 8 patients with sleep apnea syndrome (SAS) with the results of 10 normal men. Upper airway pressures were measured with two low-bias flow catheters; one was placed at the tip of the epiglottis and the other above the uvula. Nasal and pharyngeal resistances were calculated at isoflow. During CO2 rebreathing and during the 2 min after maximal voluntary hyperventilation, we continuously recorded upper airway pressures, airflow, end-tidal CO2, and the mean inspiratory flow (VT/TI); inspiratory pressure generated at 0.1 s after the onset of inspiration (P0.1) was measured every 15-20 s. In both groups upper airway resistance decreased as P0.1 increased during CO2 rebreathing. When P0.1 increased by 500%, pharyngeal resistance decreased to 17.8 +/- 3.1% of base-line values in SAS patients and to 34.9 +/- 3.4% in normal subjects (mean +/- SE). During the posthyperventilation period the VT/TI fell below the base-line level in seven SAS patients and in seven normal subjects. The decrease in VT/TI was accompanied by an increase in upper airway resistance. When the VT/TI decreased by 30% of its base-line level, pharyngea...Continue Reading

Citations

Nov 17, 2005·Journal of Applied Physiology·Clodagh M Ryan, T Douglas Bradley
Oct 7, 2006·American Journal of Respiratory and Critical Care Medicine·Matthias EikermannJürgen Peters
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·F SérièsT Similowski
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·E SforzaJ Krieger
Jan 31, 2002·Upsala Journal of Medical Sciences·A Elmasry
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·S RedlineM D Altose
Apr 20, 2013·Journal of Applied Physiology·Ailiang XieJerome A Dempsey
Dec 1, 1994·European Journal of Clinical Investigation·M C CotéY Cormier
Aug 20, 2004·American Journal of Respiratory and Critical Care Medicine·Andrew WellmanDavid P White
Feb 11, 1998·The Journal of Physiology·O PierreficheK M Spyer

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