Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials

Critical Care : the Official Journal of the Critical Care Forum
Qi-Hong ChenRui-Qiang Zheng

Abstract

Restrictive red blood cell transfusion strategies remain controversial in patients undergoing cardiac surgery. We performed a meta-analysis to assess the prognostic benefits of restrictive red blood cell transfusion strategies in patients undergoing cardiac surgery. We identified randomized clinical trials through the 9th of December 2017 that investigated a restrictive red blood cell transfusion strategy versus a liberal transfusion strategy in patients undergoing cardiac surgery. Individual patient data from each study were collected. Meta-analyses were performed for the primary and secondary outcomes. The risk of bias was assessed using the Cochrane Risk of Bias Tool. A trial sequential analysis (TSA)-adjusted random-effects model was used to pool the results from the included studies for the primary outcomes. Seven trials involving a total of 8886 patients were included. The TSA evaluations suggested that this meta-analysis could draw firm negative results, and the data were sufficient. There was no evidence that the risk of 30-day mortality differed between the patients assigned to a restrictive blood cell transfusion strategy and a liberal transfusion strategy (odds ratio (OR) 0.98; 95% confidence interval (CI) 0.77 to 1....Continue Reading

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Feb 27, 2019·Critical Care Nursing Quarterly·Michelle Keasling Jankite
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Aug 28, 2018·The New England Journal of Medicine·C David MazerUNKNOWN TRICS Investigators and Perioperative Anesthesia Clinical Trials Group

Jul 29, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Jul 28, 2020·Anaesthesia Critical Care & Pain Medicine·Sigismond LasockiGérald Chanques
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Jul 5, 2021·The Annals of Thoracic Surgery·Pierre TibiSusan Moffatt-Bruce
Jul 5, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Pierre TibiSusan Moffatt-Bruce
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Aug 27, 2021·The Annals of Thoracic Surgery·Qiaoni ZhangBingyang Ji

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Methods Mentioned

BETA
coronary artery bypass

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